CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2284
Family Name Serine/threonine-protein kinase mTOR and RAC-alpha serine/threonine-protein kinase inhibitor AGN-PC-08783I family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00332200 Functional Category Bioactive
Superfamily Macrophage colony-stimulating factor 1 receptor and Serine/threonine-protein kinase mTOR Binder Superfamily
Class Class 1031

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
GDC-0349 family 44 77
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Class II cytokine receptor Ligand IL-10 Family 7 45
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6 Inhibi... 2 3
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Prothrombin inhibitor SureCN5856722 family 3 16
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Epidermal growth factor receptor ligand pyrido[4,3-d]pyrimidin... 11 0
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Transient receptor potential cation channel subfamily V member... 2 1
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Transient receptor potential cation channel subfamily V member... 4 0
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Substance-P receptor ligand Netupitant family 5 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Transient receptor potential cation channel subfamily V member... 3 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 4 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Glycogen synthase kinase-3 beta inhibitor SureCN13987027 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00332200 CHEMBL1258910 Bioactive AGN-PC-08783I
CFAMM00332207 CHEMBL1257295 Bioactive AGN-PC-08783H

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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