CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2297
Family Name Glucocorticoid receptor ligand 4-fluoro-2-[5,5,5-trifluoro-4-hydroxy-2-methyl-4-[[(2-methylquinolin-5-yl)amino]methyl]pentan-2-yl]phenol family
No. of Seeds 3 No. of Other Members 9
Family Centroid CFAMM00332308 Functional Category Bioactive
Superfamily Cholinesterase and Androgen receptor Binder Superfamily
Class Class 770

Cousin Family NamesSeedsMembers
Histamine N-methyltransferase inhibitor aminoquinoline Amodiaq... 8 23
Phospholipase A2 Inhibitor Quinacrine Family 13 95
E3 ubiquitin-protein ligase Mdm2 Inhibitor NSC-66811 Family 4 27
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 5 40
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 10
Glucocorticoid receptor and Progesterone receptor ligand AGN-P... 3 3
Glucocorticoid receptor and Progesterone receptor ligand AGN-P... 9 6
Survival motor neuron protein and Ferritin light chain inhibit... 1 25
Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9
Androgen receptor ligand (6R,7S)-6-ethyl-7-methyl-4-(trifluoro... 22 29
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 4 0
Glucocorticoid receptor ligand 1,1,1-trifluoro-2-[(1-methyl-3,... 3 4
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
Glucocorticoid receptor ligand 1,1,1-trifluoro-2-[(1-methyl-3,... 5 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1


External ID

Functional Category

Molecule Name

CFAMM00332309 CHEMBL1257454 Bioactive 1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-[[(2-methylquinolin-5-yl)amino]methyl]pentan-2-ol
CFAMM00332308 CHEMBL1257572 Bioactive 4-fluoro-2-[5,5,5-trifluoro-4-hydroxy-2-methyl-4-[[(2-methylquinolin-5-yl)amino]methyl]pentan-2-yl]phenol
CFAMM00332307 CHEMBL1257453 Bioactive 4-fluoro-2-[5,5,5-trifluoro-4-hydroxy-2-methyl-4-[(quinolin-5-ylamino)methyl]pentan-2-yl]phenol

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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