CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2298
Family Name Potassium voltage-gated channel subfamily H member 2 and Kappa-type opioid receptor ligand 3-[[(1R,5S)-8-(pyridin-3-ylmethyl)-8-azabicyclo[3.2.1]octan-3-yl]oxy]benzamide family
No. of Seeds 5 No. of Other Members 33
Family Centroid CFAMM00267405 Functional Category Bioactive with Natural Product
Superfamily Delta-type opioid receptor and Mu-type opioid receptor Ligand 6-(2-phenethylisoindolin-5-yloxy)nicotinamide Superfamily
Class Class 2449

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Peroxisome proliferator-activated receptor gamma Ligand Piogli... 2 29
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Histamine H3 receptor Ligand GSK239512 Family 2 65
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Sodium-dependent noradrenaline transporter Inhibitor Neri Iv F... 6 58
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Smoothened homolog Inhibitor LDE225 Family 3 76
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Glucokinase Inhibitor GKA1 Family 2 67
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Renin Inhibitor CP-305202 Family 9 30
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-[3... 1 2
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Neutrophil elastase inhibitor phenyl N-[(2S)-1-[(2S)-2-[[(3S)-... 2 0
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07ZA5M family 4 14
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
cAMP-dependent protein kinase type II-alpha regulatory subunit... 2 4
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Somatostatin receptor type 5 ligand AGN-PC-088VSK family 2 3
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Vasopressin V1b receptor ligand 2-[3-(3-chlorophenyl)-7-[3-(3-... 8 17
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
Sodium channel protein type 10 subunit alpha and Sodium channe... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 17
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
Cytochrome P450 2C19 and Inositol monophosphatase 1 inhibitor ... 1 0
Histamine H3 receptor ligand SureCN2784306 family 5 3
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 14
Histamine H3 receptor ligand 3-[4-[3-[(2R)-2-methylpyrrolidin-... 1 5
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Mu-type opioid receptor ligand AGN-PC-075GEP family 1 2
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 10 15
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 7
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 1 13
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 2
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histamine H3 receptor ligand 6-[[2-[2-[(2R)-2-methylpyrrolidin... 2 0
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
G-protein coupled bile acid receptor 1 ligand (4-cyclopropyl-2... 2 1
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cGMP-inhib... 18 10
Motilin receptor ligand SureCN2768193 family 2 1
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
C-C chemokine receptor type 5 ligand N-methyl-4-[6-methyl-5-[[... 2 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... 1 8
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
Coagulation factor X inhibitor 3-Oxybenzamide 48 family 1 12
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Pol polyprotein inhibitor Tertiary Amide deriv. 58 family 1 0
CGMP-dependent protein kinase inhibitor AGN-PC-075IHL family 2 8
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 4 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 4 3
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 1 3
72 kDa type IV collagenase and Aminopeptidase N inhibitor ly52... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 2 2
Renin inhibitor SureCN7300793 family 2 5
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 2 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 3
Ectonucleotide pyrophosphatase/phosphodiesterase family member... 1 0
Platelet-activating factor receptor ligand [(2R,4R)-4-(octadec... 3 2
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 2 3
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 1 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Coagulation factor X inhibitor 3-Oxybenzamide 15 family 1 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9RLJ family 1 0
Collagenase 3 inhibitor 4-[4-[2-[(3S)-3-hydroxy-1-azabicyclo[2... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00332318 CHEMBL1258962 Bioactive 3-[[(1R,5S)-8-(1-pyridin-4-ylethyl)-8-azabicyclo[3.2.1]octan-3-yl]oxy]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27432 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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