CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2299
Family Name RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-amino-1-[4-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-2-(3,4-dichlorophenyl)propan-1-one family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00332351 Functional Category Bioactive
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Binder Superfamily 13
Class Class 2337

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Translocator protein Inhibitor Emapunil Family 7 89
Adenosine receptor A1 Ligand SLV320 Family 6 79
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
RAC-gamma serine/threonine-protein kinase Inhibitor GDC-0068 F... 20 29
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Histamine H3 receptor Ligand SCH79687 Family 11 29
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5856722 family 3 16
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Prelamin-A/C and Lethal(3)malignant brain tumor-like protein 1... 1 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(4-chlo... 11 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Signal transducer and activator of transcription 6 inhibitor A... 3 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 1 0
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(1H-pyr... 2 8
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Cathepsin K inhibitor CHEMBL2163360 family 1 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 2 0
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 6 3
P2X purinoceptor 7 inhibitor SureCN1635928 family 4 4
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... 2 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Cathepsin K inhibitor SureCN4138062 family 7 0
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Bifunctional epoxide hydrolase 2 and Potassium voltage-gated c... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00332352 CHEMBL1258900 Bioactive SureCN13229981
CFAMM00332351 CHEMBL1257512 Bioactive (2S)-3-amino-1-[4-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-2-(3,4-dichlorophenyl)propan-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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