CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2318
Family Name Neuropeptide Y receptor type 5 ligand 8-[[[6-(2-fluorophenyl)pyridazin-3-yl]amino]methyl]-3-pyridazin-3-yl-1-oxa-3-azaspiro[4.5]decan-2-one family
No. of Seeds 6 No. of Other Members 0
Family Centroid CFAMM00332553 Functional Category Bioactive
Superfamily Neuropeptide Y receptor type 5 and Epidermal growth factor receptor Binder Superfamily
Class Class 3224

Cousin Family NamesSeedsMembers
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor PF-0048... 2 13
GDC-0349 family 44 77
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Potassium vol... 13 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Proto-oncogene tyrosine-protein kinase Src and Mast/stem cell ... 4 1
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 11 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0


External ID

Functional Category

Molecule Name

CFAMM00332557 CHEMBL1258907 Bioactive 8-[[[5-(3-fluoropyridin-2-yl)pyridin-2-yl]amino]methyl]-3-pyridazin-3-yl-1-oxa-3-azaspiro[4.5]decan-2-one
CFAMM00332556 CHEMBL1257992 Bioactive 8-[[[6-(2-fluorophenyl)pyridazin-3-yl]amino]methyl]-3-pyridin-2-yl-1-oxa-3-azaspiro[4.5]decan-2-one
CFAMM00332555 CHEMBL1258788 Bioactive 8-[[[5-(6-methylpyridin-2-yl)pyridin-2-yl]amino]methyl]-3-pyridazin-3-yl-1-oxa-3-azaspiro[4.5]decan-2-one
CFAMM00332554 CHEMBL1258674 Bioactive 8-[[[6-(3,5-difluorophenyl)pyridazin-3-yl]amino]methyl]-3-pyridazin-3-yl-1-oxa-3-azaspiro[4.5]decan-2-one
CFAMM00332553 CHEMBL1258673 Bioactive 8-[[[6-(2-fluorophenyl)pyridazin-3-yl]amino]methyl]-3-pyridazin-3-yl-1-oxa-3-azaspiro[4.5]decan-2-one
CFAMM00332558 CHEMBL1258787 Bioactive 8-[[[6-(2-methylphenyl)pyridazin-3-yl]amino]methyl]-3-pyridazin-3-yl-1-oxa-3-azaspiro[4.5]decan-2-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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