CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhibited 3',5'-cyclic phosphodiesterase A inhibitor AGN-PC-00MUI6 family
No. of Seeds 28 No. of Other Members 91
Family Centroid CFAMM00309209 Functional Category Bioactive with Natural Product
Superfamily Beta-lactamase and Survival motor neuron protein Binder Superfamily
Class Class 1484

Cousin Family NamesSeedsMembers
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 0
Beta-secretase 1 inhibitor SureCN8235614 family 4 4
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Survival motor neuron protein and Alpha-galactosidase A inhibi... 1 4
Vasopressin V1b receptor ligand AGN-PC-09QGT9 family 4 123
Vasopressin V1b receptor ligand AGN-PC-00HJ2S family 4 6
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor SureC... 2 3
Ghrelin/growth hormone secretagogue receptor and Cytochrome P4... 5 20
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 16 2
Histamine H3 receptor ligand AGN-PC-00AE5Q family 13 13
Histamine H3 receptor and Potassium voltage-gated channel subf... 28 30


External ID

Functional Category

Molecule Name

CFAMM00309216 CHEMBL327808 Bioactive AGN-PC-003B5A
CFAMM00309244 CHEMBL108741 Bioactive AGN-PC-00NV2D
CFAMM00309209 CHEMBL108914 Bioactive AGN-PC-00MUI6
CFAMM00309250 CHEMBL327786 Bioactive 7-[4-[4-(cyclohexylmethyl)piperazin-1-yl]-4-oxobutoxy]-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one
CFAMM00309263 CHEMBL109096 Bioactive AGN-PC-00MUIB
CFAMM00309282 CHEMBL68378 Bioactive AGN-PC-074FDS
CFAMM00309249 CHEMBL110338 Bioactive AGN-PC-00NV2B
CFAMM00309192 CHEMBL107939 Bioactive AGN-PC-00NV2C
CFAMM00309255 CHEMBL110350 Bioactive AGN-PC-00NV3S
CFAMM00309261 CHEMBL105793 Bioactive AGN-PC-00MCYB
CFAMM00309219 CHEMBL69139 Bioactive Lixazinone
CFAMM00309280 CHEMBL419368 Bioactive AGN-PC-00MCY6
CFAMM00309199 CHEMBL326891 Bioactive AGN-PC-074WLL
CFAMM00309212 CHEMBL106922 Bioactive AGN-PC-00MUI5
CFAMM00309286 CHEMBL324011 Bioactive AGN-PC-00MUI2
CFAMM00309225 CHEMBL109149 Bioactive AGN-PC-074WL9
CFAMM00309253 CHEMBL110374 Bioactive AGN-PC-00NV2L
CFAMM00309292 CHEMBL108876 Bioactive AGN-PC-074WJO
CFAMM00309306 CHEMBL107651 Bioactive AGN-PC-074WLC
CFAMM00309279 CHEMBL109062 Bioactive AGN-PC-00NV2E
CFAMM00309198 CHEMBL322596 Bioactive AGN-PC-00NV2J
CFAMM00309189 CHEMBL321600 Bioactive AGN-PC-00NV2A
CFAMM00309272 CHEMBL68848 Bioactive AGN-PC-074FBJ
CFAMM00309204 CHEMBL66973 Bioactive AGN-PC-02N2OU
CFAMM00309265 CHEMBL106141 Bioactive N-cyclohexyl-N-methyl-4-[[(3R)-3-methyl-2-oxo-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-7-yl]oxy]butanamide
CFAMM00309195 CHEMBL107034 Bioactive AGN-PC-00MUI0
CFAMM00309278 CHEMBL110172 Bioactive AGN-PC-00MUI3
CFAMM00309230 CHEMBL110484 Bioactive AGN-PC-00MCY7

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

Last update by



71581 visits since 2014 .........


Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

All rights reserved.

Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links


Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543