CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2344
Family Name Translocator protein inhibitor AGN-PC-080ILF family
No. of Seeds 9 No. of Other Members 3
Family Centroid CFAMM00332959 Functional Category Bioactive
Superfamily Integrin beta-3 and Integrin alpha-V Binder Superfamily 10
Class Class 851

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Corticotropin-releasing factor receptor 1 Ligand GSK561679 Family 5 6
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Ibrutinib family 2 27
Tyrosine kinase Inhibitor PKI166 Family 17 198
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CC4... 20 7
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 12 8
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 5
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 4
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 1
Neuropeptide Y receptor type 1 ligand CP-671906 family 10 0
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Corticotropin-releasing factor receptor 1 ligand CHEMBL1819076... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 17
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 4 4
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 0
Estrogen receptor and Estrogen receptor beta ligand 4-[3-[4-(2... 1 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 7 6
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
Adenosine receptor A2a ligand AGN-PC-077RYF family 3 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CCL... 3 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CCI... 3 0
Aurora kinase A and Glycogen synthase kinase-3 beta inhibitor ... 1 2
Tyrosine-protein kinase Lck inhibitor AGN-PC-07R5ZB family 4 3
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00332972 CHEMBL469682 Bioactive AGN-PC-04TFZN
CFAMM00332971 CHEMBL1258722 Bioactive AGN-PC-080ILG
CFAMM00332951 CHEMBL2336480 Bioactive 2-[5,7-diethyl-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide
CFAMM00332970 CHEMBL1258723 Bioactive AGN-PC-080ILH
CFAMM00332969 CHEMBL480041 Bioactive N,N-diethyl-2-[2-(4-methoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]acetamide
CFAMM00332963 CHEMBL512306 Bioactive AGN-PC-045KG3
CFAMM00332959 CHEMBL1258614 Bioactive AGN-PC-080ILF
CFAMM00332973 CHEMBL1258843 Bioactive AGN-PC-080ILI
CFAMM00332957 CHEMBL2336474 Bioactive 2-[5,7-diethyl-2-[4-(2-fluoroethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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