CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2345
Family Name Mitogen-activated protein kinase 14 and LIM domain kinase 1 inhibitor AGN-PC-09M5AV family
No. of Seeds 4 No. of Other Members 19
Family Centroid CFAMM00310695 Functional Category Bioactive
Superfamily Beta-lactamase and Cytochrome P450 2D6 Binder Superfamily 2
Class Class 3543

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Cyclin-dependent kinase 2 Inhibitor 4-(2,4-dimethyl-thiazol-5-... 2 14
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
TGF-beta receptor type-1 Ligand 4-pyridin-2-yl-5-quinolin-4-yl... 4 23
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Metabotropic glutamate receptor 5 Ligand 4-(4-chlorophenylthio... 4 17
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Histamine H3 receptor Ligand 2-(1,4'-bipiperidin-1'-yl)thiazol... 2 23
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-264... 6 32
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 2 7
Mitogen-activated protein kinase 14 inhibitor 6-[3-amino-5-(2-... 4 9
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
5-hydroxytryptamine receptor 6 ligand 6-chloro-5-[1-(1-methylp... 9 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M88D fa... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Adenosine kinase inhibitor SureCN8183719 family 2 3
Amine oxidase [flavin-containing] B inhibitor 4-(4-fluoropheny... 3 4
Platelet-activating factor receptor ligand Foropafant family 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Histamine H4 receptor ligand 8-chloro-4-[(3R)-3-(methylamino)p... 3 10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-[2-[(4-mor... 2 3
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 1
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
Cyclin-dependent kinase 6 and Cyclin-dependent kinase 4 inhibi... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Tyrosine-protein kinase JAK2 and Cytochrome P450 3A4 inhibitor... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
G1/S-specific cyclin-E1 and G1/S-specific cyclin-E2 inhibitor ... 5 1
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor CDK Inhibito... 8 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 5-[5-chloro-... 2 18
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Tyrosine-protein kinase ITK/TSK and Tyrosine-protein kinase Lc... 2 2
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Platelet-activating factor receptor ligand SureCN9378808 family 3 0
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Histamine H4 receptor and Histamine H1 receptor ligand 6-chlor... 1 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
Transient receptor potential cation channel subfamily V member... 9 13
Epidermal growth factor receptor ligand AGN-PC-00RWHW family 3 4
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Transient receptor potential cation channel subfamily V member... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck ligand... 1 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 1
Dihydrofolate reductase inhibitor 5-[(7-chloro-10-methylsulfan... 1 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00332986 CHEMBL1258741 Bioactive N-[(2S)-butan-2-yl]-5-[6-(2-chlorophenyl)-2-pyridin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-amine
CFAMM00332985 CHEMBL1258742 Bioactive N-[(2R)-butan-2-yl]-5-[6-(2-chlorophenyl)-2-pyridin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-amine
CFAMM00332983 CHEMBL1258976 Bioactive AGN-PC-09M9O2

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27284 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543