CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2353
Family Name Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ligand AGN-PC-087U9C family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00333086 Functional Category Bioactive
Superfamily Integrin beta-2 and Alpha-1A adrenergic receptor Binder Superfamily
Class Class 3189

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Platelet-derived growth factor receptor alpha and Platelet-der... 5 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22
Cytochrome P450 3A4 Inhibitor 3-(3-methylthiophen-2-yl)pyridin... 5 27
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 16
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... 8 25
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 8
D(2) dopamine receptor and D(3) dopamine receptor ligand 8-chl... 6 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 1 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 5 10
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 3 7
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 8 6
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1,1,1... 12 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor [1-[4... 2 0
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 2 9
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 1 3
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 4 2
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 4 2
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 3 3
Metabotropic glutamate receptor 5 and Cytochrome P450 1A2 liga... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00333086 CHEMBL1259023 Bioactive AGN-PC-087U9C
CFAMM00333085 CHEMBL1259006 Bioactive AGN-PC-087U9B
CFAMM00333084 CHEMBL1259024 Bioactive AGN-PC-087U9D

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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