CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2357
Family Name Lysosomal Pro-X carboxypeptidase inhibitor 2-amino-N-[(2S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-(4-phenylphenyl)propan-2-yl]-2-methylpropanamide family
No. of Seeds 11 No. of Other Members 16
Family Centroid CFAMM00307292 Functional Category Bioactive
Superfamily Lysosomal Pro-X carboxypeptidase Binder Superfamily
Class Class 1016

Cousin Family NamesSeedsMembers
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
BIBT986 family 7 96
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Histamine H3 receptor Ligand SCH79687 Family 11 29
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 0
Lysosomal Pro-X carboxypeptidase inhibitor N-[(2S)-1-[(2S)-2-(... 1 0
Histamine H4 receptor ligand (2Z)-5-chloro-2-[(1-methylpiperid... 2 8
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Bile acid receptor and Potassium voltage-gated channel subfami... 2 1
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Lysosomal Pro-X carboxypeptidase inhibitor 1-[(2S)-2-(5,6-dich... 3 10
Lysosomal Pro-X carboxypeptidase inhibitor 1-[(2S)-2-(5,6-dich... 2 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 14
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 1 0
Cannabinoid receptor 1 ligand SureCN675796 family 5 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 13
Coagulation factor X inhibitor SureCN8289965 family 4 5
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-N-[(1S)-1-(... 1 0
Melanin-concentrating hormone receptor 1 ligand 3-[(1R,3R,6S)-... 6 6
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Orexin receptor type 2 and Orexin receptor type 1 ligand (2S)-... 2 2
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Diacylglycerol O-acyltransferase 1 inhibitor 2-[4-[4-[5-(6-chl... 2 0
Substance-K receptor ligand SureCN9035669 family 10 5
Coagulation factor X inhibitor SureCN1652469 family 2 1
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Melanin-concentrating hormone receptor 1 ligand SureCN3832854 ... 3 2
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Lysosomal Pro-X carboxypeptidase inhibitor 9H-fluoren-9-ylmeth... 1 1
Lysosomal Pro-X carboxypeptidase inhibitor 1-[(2S)-2-[5-(3-bro... 1 0
Lysosomal Pro-X carboxypeptidase inhibitor 3-[4-[3-[(2S,4R)-2-... 1 0
Lysosomal Pro-X carboxypeptidase inhibitor 1-[6-[(2S)-2-(5,6-d... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00333103 CHEMBL1950445 Bioactive (2S,3S)-2-amino-N-[(1S)-1-(5,6-dichloro-1H-benzimidazol-2-yl)ethyl]-3-(4-phenylphenyl)butanamide
CFAMM00333102 CHEMBL1259149 Bioactive 3-amino-N-[(2S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-(4-phenylphenyl)propan-2-yl]-2,2-dimethylpropanamide
CFAMM00333108 CHEMBL1950443 Bioactive (2S)-2-[(2-amino-2-methylpropyl)amino]-N-[(1S)-1-(5,6-dichloro-1H-benzimidazol-2-yl)ethyl]-3-(4-phenylphenyl)propanamide
CFAMM00333101 CHEMBL1259162 Bioactive 3-amino-N-[(2S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-(4-phenylphenyl)propan-2-yl]-3-methylbutanamide
CFAMM00333114 CHEMBL1259222 Bioactive 2-amino-N-[(2S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-3-[4-(1-methyl-6-oxopyridin-3-yl)phenyl]-1-oxopropan-2-yl]-2-methylpropanamide
CFAMM00333107 CHEMBL1950441 Bioactive 2-amino-N-[(2S)-3-(3-cyanophenyl)-1-[[(1S)-1-(5,6-dichloro-1H-benzimidazol-2-yl)ethyl]amino]-1-oxopropan-2-yl]-2-methylpropanamide
CFAMM00333113 CHEMBL1259208 Bioactive N-[(2S,3S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-3-[4-(4-fluorophenyl)phenyl]-1-oxobutan-2-yl]-2-hydroxy-2-methylpropanamide
CFAMM00333112 CHEMBL1259194 Bioactive 2-amino-N-[(2S,3S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-(4-phenylphenyl)butan-2-yl]-2-methylpropanamide
CFAMM00333104 CHEMBL1950444 Bioactive (2S,3S)-2-[(2-amino-2-methylpropanoyl)amino]-N-[(1S)-1-(5,6-dichloro-1H-benzimidazol-2-yl)ethyl]-3-(4-phenylphenyl)butanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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