CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2363
Family Name Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ligand SureCN6960339 family
No. of Seeds 10 No. of Other Members 1
Family Centroid CFAMM00162800 Functional Category Bioactive
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform and Serine/threonine-protein kinase mTOR Inhibitor BEZ235 Superfamily
Class Class 147

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
D(2) dopamine receptor Ligand Sertindole Family 3 173
Type-1 angiotensin II receptor Ligand Forasartan Family 3 253
Transient receptor potential cation channel subfamily V member... 15 158
Transient receptor potential cation channel subfamily V member... 12 108
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Growth hormone receptor Ligand EP-51216 Family 34 390
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Amg 423 family 7 47
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Tedizolid family 2 2
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 4 33
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Type-2 angiotensin II receptor Ligand SC-55634 Family 8 5
Prothrombin inhibitor SureCN5855286 family 15 8
Prothrombin inhibitor SureCN5854779 family 4 9
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Glucocorticoid receptor ligand N-[(3S)-3-[1-(4-fluorophenyl)in... 11 24
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 1 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Melanin-concentrating hormone receptor 1 ligand SureCN10144515... 3 6
Survival motor neuron protein and Menin inhibitor CHEMBL132797... 1 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 5 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... 5 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 2
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Cell division cycle 7-related protein kinase and Casein kinase... 2 0
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Cholecystokinin receptor type A ligand 6-[2-[2-(cyclohexylmeth... 2 6
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Growth hormone secretagogue receptor type 1 ligand SureCN36660... 4 14
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Fatty-acid amide hydrolase 1 and Monoglyceride lipase inhibito... 3 2
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1-met... 2 0
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-[2-... 9 0
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Neuropeptide Y receptor type 5 ligand AGN-PC-01NS1A family 7 0
Tyrosine-protein kinase receptor TYRO3 ligand 3-amino-6-(1H-in... 2 3
TGF-beta receptor type-1 ligand 6-bromo-4-(2-(6-methylpyridin-... 1 3
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00GCQW f... 2 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9057529 f... 2 0
TGF-beta receptor type-1 ligand SureCN373106 family 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00333185 CHEMBL1259188 Bioactive SureCN6954429

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27163 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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