CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2364
Family Name 5-hydroxytryptamine receptor 1A and D(3) dopamine receptor ligand SureCN3976254 family
No. of Seeds 2 No. of Other Members 8
Family Centroid CFAMM00333187 Functional Category Bioactive
Superfamily Macrophage metalloelastase Inhibitor PF-00356231 Superfamily
Class Class 1827

Cousin Family NamesSeedsMembers
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Integrin beta-3 Inhibitor L-739758 Family 2 4
Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thio... 9 46
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(2... 2 20
Deoxycytidine kinase inhibitor N-[(1S,3S)-3-(4-amino-5-fluoro-... 2 5
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-[4... 4 0
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Sonic hedgehog protein inhibitor 3-chloro-N-[4-(methylamino)cy... 2 3
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1231206 ... 6 7
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-073U... 3 8
Platelet-activating factor receptor ligand YM-461 family 1 11
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Neuromedin-K receptor ligand 3-methylsulfinyl-N-[(1S)-1-phenyl... 3 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 4 11
Gonadotropin-releasing hormone receptor ligand 1-[4-[1-[(2,6-d... 8 0
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 4 10
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 2
Glycogen synthase kinase-3 beta inhibitor 7-(6-chloropyridin-2... 2 3
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 8 4
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 2 0
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[acetyl(thio... 6 3
C-C chemokine receptor type 5 ligand 6-chloro-2,4-dimethyl-N-[... 1 0
Histone deacetylase 1 inhibitor N-hydroxy-5-[1-[2-[(1-methylin... 4 1
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 5 0
Histone deacetylase 1 inhibitor 5-[5-[[(2-chlorophenyl)methyla... 4 1
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 4 4
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(benzen... 4 4
Intercellular adhesion molecule 1 and E-selectin inhibitor Sur... 1 0
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand N-... 1 1
Metabotropic glutamate receptor 5 ligand 2-(2-pyridin-3-ylethy... 1 2
1-(thiophen-2-yl)-8H-benzo[c]indolo[3,2,1-ij][1,5]naphthyridin... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00333194 CHEMBL185780 Bioactive AGN-PC-075GG3
CFAMM00333187 CHEMBL1259241 Bioactive SureCN3976254

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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