CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2370
Family Name Aurora kinase A inhibitor AGN-PC-00BCUF family
No. of Seeds 16 No. of Other Members 43
Family Centroid CFAMM00333230 Functional Category Bioactive
Superfamily Aurora kinase A and Receptor-type tyrosine-protein kinase FLT3 Binder Superfamily
Class Class 1144

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Dual specificity mitogen-activated protein kinase kinase 1 inh... 10 54
Dual specificity mitogen-activated protein kinase kinase 1 inh... 5 7
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Rho-associated protein kinase 2 inhibitor SureCN13457044 family 1 17
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 20
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 3
Receptor-type tyrosine-protein kinase FLT3 ligand 2-(6,7-dimet... 3 2
Inositol monophosphatase 1 and Microtubule-associated protein ... 1 12
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Dual specificity protein kinase CLK4 and Dual specificity tyro... 1 14
Adenosine kinase inhibitor SureCN8134468 family 3 7
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Survival motor neuron protein and Microtubule-associated prote... 1 20
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 3 21
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Platelet-derived growth factor receptor beta ligand AGN-PC-075... 3 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Platelet-derived growth factor receptor beta and Macrophage co... 1 0
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 4 2
Deoxycytidine kinase inhibitor 2-[5-[4-[(4,6-diaminopyrimidin-... 14 11
Histone-lysine N-methyltransferase EHMT2 inhibitor N-(1-cyclop... 1 2
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-(3-c... 3 3
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 2 1
Vascular endothelial growth factor receptor 2 and Platelet-der... 1 0
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
Vascular endothelial growth factor receptor 2 ligand aminothia... 1 1
Potassium-transporting ATPase alpha chain 1 and Potassium-tran... 2 11
Serine/threonine-protein kinase ATR inhibitor 4-[2-(6-methoxy-... 1 0
DNA-(apurinic or apyrimidinic site) lyase and DNA polymerase b... 1 0
Glucokinase inhibitor 4-methyl-N-[3-phenylmethoxy-5-(pyridin-2... 1 8
Cysteinyl leukotriene receptor 1 and Platelet-activating facto... 1 1
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 2 0
Epidermal growth factor receptor ligand AGN-PC-07C0GB family 1 0
Glucokinase inhibitor AGN-PC-03ZE4O family 4 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00333263 CHEMBL518981 Bioactive AGN-PC-077T7J
CFAMM00333242 CHEMBL482774 Bioactive AGN-PC-077T6S
CFAMM00333235 CHEMBL201953 Bioactive AGN-PC-00DOPH
CFAMM00333227 CHEMBL201655 Bioactive AGN-PC-00D34E
CFAMM00333241 CHEMBL202593 Bioactive AGN-PC-00E8Z1
CFAMM00333220 CHEMBL201307 Bioactive N-(3-fluorophenyl)-2-[2-[[7-[3-[4-(hydroxymethyl)piperidin-1-yl]propoxy]-6-methoxyquinazolin-4-yl]amino]-1,3-thiazol-5-yl]acetamide
CFAMM00333247 CHEMBL373013 Bioactive AGN-PC-00BCMZ
CFAMM00333274 CHEMBL202567 Bioactive AGN-PC-00DOGW
CFAMM00333240 CHEMBL202198 Bioactive AGN-PC-00AGEX
CFAMM00333267 CHEMBL381721 Bioactive AGN-PC-00AM1W
CFAMM00333260 CHEMBL126192 Bioactive SureCN7093961
CFAMM00333239 CHEMBL380478 Bioactive N-(3-fluorophenyl)-2-[2-[[7-[3-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]propoxy]-6-methoxyquinazolin-4-yl]amino]-1,3-thiazol-5-yl]acetamide
CFAMM00333253 CHEMBL377289 Bioactive AGN-PC-00BYCP
CFAMM00333251 CHEMBL201197 Bioactive N-(2,3-difluorophenyl)-2-[2-[[7-[3-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]propoxy]-6-methoxyquinazolin-4-yl]amino]-1,3-thiazol-5-yl]acetamide
CFAMM00333230 CHEMBL202241 Bioactive AGN-PC-00BCUF
CFAMM00333250 CHEMBL201297 Bioactive AGN-PC-00CDCJ

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27515 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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