CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2378
Family Name Epidermal growth factor receptor ligand AGN-PC-076GVG family
No. of Seeds 8 No. of Other Members 1
Family Centroid CFAMM00333417 Functional Category Bioactive
Superfamily Epidermal growth factor receptor and Binder Superfamily
Class Class 202

Cousin Family NamesSeedsMembers
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
Transient receptor potential cation channel subfamily V member... 15 457
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
GDC-0349 family 44 77
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Metabotropic glutamate receptor 5 Ligand 2-(3-bromophenyl)-7-m... 3 1
Adenosine kinase inhibitor abt-702 family 14 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Aurora kinase A inhibitor AGN-PC-07ZZEH family 2 4
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Adenosine kinase inhibitor 5-[3-(3-bromophenyl)propyl]-6-[2-(6... 3 0
Epidermal growth factor receptor ligand pyrido[4,3-d]pyrimidin... 11 0
Epidermal growth factor receptor ligand AGN-PC-076GXM family 6 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Dihydrofolate reductase inhibitor AC1LAKQL family 3 1
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Transient receptor potential cation channel subfamily V member... 4 0
Epidermal growth factor receptor ligand AGN-PC-076GWD family 2 0
Epidermal growth factor receptor ligand Pyrroloquinazoline der... 7 0
Epidermal growth factor receptor ligand AGN-PC-078X7L family 4 0
Epidermal growth factor receptor ligand (E)-N-[4-(3-bromoanili... 2 1
Epidermal growth factor receptor ligand AGN-PC-073LJS family 4 0
Epidermal growth factor receptor ligand 4-Anilinopyrido[3,4-d]... 2 0
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Epidermal growth factor receptor ligand AGN-PC-078X9P family 4 0
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0
Adenosine kinase inhibitor AGN-PC-074DKZ family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00333413 CHEMBL127611 Bioactive pyrido[4,3-d]pyrimidine deriv. 3k
CFAMM00333411 CHEMBL340700 Bioactive pyrido[4,3-d]pyrimidine deriv. 3g
CFAMM00333417 CHEMBL270695 Bioactive AGN-PC-076GVG
CFAMM00333410 CHEMBL271623 Bioactive AGN-PC-076GVU
CFAMM00333416 CHEMBL427832 Bioactive AGN-PC-076GV6
CFAMM00333409 CHEMBL410635 Bioactive AGN-PC-076GV8
CFAMM00333415 CHEMBL129579 Bioactive pyrido[4,3-d]pyrimidine deriv. 3j
CFAMM00333414 CHEMBL126372 Bioactive pyrido[4,3-d]pyrimidine deriv. 3f

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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