CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2379
Family Name Microsomal triglyceride transfer protein large subunit inhibitor N-[(1S)-2-[ethyl(propyl)amino]-2-oxo-1-phenylethyl]-2-methoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzamide family
No. of Seeds 4 No. of Other Members 5
Family Centroid CFAMM00333418 Functional Category Bioactive
Superfamily Microsomal triglyceride transfer protein large subunit and Cytochrome P450 3A4 Binder Superfamily
Class Class 2499

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Nemonapride Family 70 283
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Trace amine-associated receptor 1 ligand EPPTB family 4 9
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Microsomal triglyceride transfer protein large subunit inhibit... 3 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 4 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 0
Histone deacetylase 1 and Histone deacetylase 2 inhibitor Sure... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00333427 CHEMBL210048 Bioactive 2-methoxy-N-[(1S)-2-oxo-1-phenyl-2-piperidin-1-ylethyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzamide
CFAMM00333418 CHEMBL210796 Bioactive N-[(1S)-2-[ethyl(propyl)amino]-2-oxo-1-phenylethyl]-2-methoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzamide
CFAMM00333425 CHEMBL207461 Bioactive 2-methoxy-N-[(1S)-2-oxo-1-phenyl-2-pyrrolidin-1-ylethyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzamide
CFAMM00333424 CHEMBL126377 Bioactive N-[(1S)-2-(cyclopropylmethylamino)-2-oxo-1-phenylethyl]-2-methoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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