CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2382
Family Name Sodium-dependent serotonin transporter and 5-hydroxytryptamine receptor 1A ligand SureCN5480892 family
No. of Seeds 8 No. of Other Members 12
Family Centroid CFAMM00256502 Functional Category Bioactive with Natural Product
Superfamily 5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin transporter Ligand Vilazodone Superfamily
Class Class 656

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
D(2) dopamine receptor Ligand SLV-314 Family 19 69
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 391
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 9 12
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Ferritin light chain and Ras-related protein Rab-9A inhibitor ... 1 11
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 11 11
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 7 1
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Cholinesterase and Acetylcholinesterase inhibitor 5-hydroxy-7-... 5 19
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
C-C chemokine receptor type 3 and Histamine H1 receptor ligand... 2 2
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 4 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Substance-P receptor ligand SureCN2139814 family 7 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 1
RAC-alpha serine/threonine-protein kinase inhibitor Isoquinoli... 1 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PI... 4 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Glycogen synthase kinase-3 beta inhibitor bip-135 family 3 1
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 6 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Protein kinase C theta type and Protein kinase C delta type in... 13 0
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
Collagenase 3 inhibitor SureCN1316041 family 4 3
Sodium-dependent serotonin transporter inhibitor SureCN5477150... 4 1
Survival motor neuron protein and Arachidonate 15-lipoxygenase... 1 2
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 3
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
ATP-binding cassette sub-family G member 2 inhibitor 5-[(4-bro... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00333447 CHEMBL599077 Bioactive AGN-PC-005WAY
CFAMM00333454 CHEMBL597479 Bioactive SureCN5474288
CFAMM00333463 CHEMBL596665 Bioactive SureCN5468537

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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