CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2396
Family Name P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methyl]-3-ethyl-1-methyl-2-oxoimidazolidine-4-carboxamide family
No. of Seeds 16 No. of Other Members 11
Family Centroid CFAMM00333558 Functional Category Bioactive
Superfamily Beta-lactamase and P2X purinoceptor 7 Binder Superfamily 2
Class Class 3485

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Mephenytoin... 5 51
Acetylcholinesterase Inhibitor Ambenonium Family 4 71
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Dipeptidyl peptidase 4 Inhibitor 1-benzyl-4-(2,4-dichloropheny... 2 10
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Sodium-dependent serotonin transporter Inhibitor Irindalone Fa... 16 9
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 4 13
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 7 9
Prothrombin inhibitor (2S)-N-[[2-(aminomethyl)-5-chlorophenyl]... 5 11
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 10 18
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 6
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 7 16
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Prothrombin inhibitor SureCN6921523 family 4 1
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
P2X purinoceptor 7 inhibitor (2S)-N-[[2-chloro-3-(trifluoromet... 3 0
P2X purinoceptor 7 inhibitor (4S)-3-methyl-N-[[2-methyl-3-(tri... 3 0
P2X purinoceptor 7 inhibitor (3S)-N-[[2-chloro-3-(trifluoromet... 1 6
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 6 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 1
Bifunctional epoxide hydrolase 2 inhibitor SureCN13873320 family 1 5


External ID

Functional Category

Molecule Name

CFAMM00333546 CHEMBL2218383 Bioactive (4S)-N-[(2,4-dichloro-6-methylphenyl)methyl]-1,3-dimethyl-2-oxoimidazolidine-4-carboxamide
CFAMM00333560 CHEMBL1269249 Bioactive (4S)-N-[(2,4-dichlorophenyl)methyl]-3-methyl-2-oxoimidazolidine-4-carboxamide
CFAMM00333553 CHEMBL2218573 Bioactive SureCN1636078
CFAMM00333567 CHEMBL2218569 Bioactive (4S)-1,3-dimethyl-2-oxo-N-[(2,4,6-trichlorophenyl)methyl]imidazolidine-4-carboxamide
CFAMM00333559 CHEMBL1269248 Bioactive (4S)-N-[(2,4-dichlorophenyl)methyl]-1,3-dimethyl-2-oxoimidazolidine-4-carboxamide
CFAMM00333558 CHEMBL2218173 Bioactive (4S)-N-[(2,4-dichlorophenyl)methyl]-3-ethyl-1-methyl-2-oxoimidazolidine-4-carboxamide
CFAMM00333543 CHEMBL2218369 Bioactive (4S)-N-[(2,4-dichloro-6-methylphenyl)methyl]-3-methyl-2-oxoimidazolidine-4-carboxamide
CFAMM00333557 CHEMBL2218575 Bioactive SureCN1637514
CFAMM00333563 CHEMBL2218563 Bioactive (4S)-N-[(2,4-dichlorophenyl)methyl]-3-methyl-2-oxo-1-(2,2,2-trifluoroethyl)imidazolidine-4-carboxamide
CFAMM00333556 CHEMBL2218570 Bioactive (4S)-3-methyl-2-oxo-N-[(2,4,6-trichlorophenyl)methyl]imidazolidine-4-carboxamide
CFAMM00333570 CHEMBL2218565 Bioactive (4S)-N-[(2,4-dichlorophenyl)methyl]-1-ethyl-3-methyl-2-oxoimidazolidine-4-carboxamide
CFAMM00333548 CHEMBL2218559 Bioactive (4S)-N-[(2,4-dichlorophenyl)methyl]-1-(2,2-difluoroethyl)-3-methyl-2-oxoimidazolidine-4-carboxamide
CFAMM00333562 CHEMBL2218564 Bioactive (4S)-N-[(2,4-dichlorophenyl)methyl]-1-(2-fluoroethyl)-3-methyl-2-oxoimidazolidine-4-carboxamide
CFAMM00333555 CHEMBL2218571 Bioactive SureCN1637943
CFAMM00333561 CHEMBL2218568 Bioactive (4S)-N-[(2,4-dichloro-6-fluorophenyl)methyl]-1,3-dimethyl-2-oxoimidazolidine-4-carboxamide
CFAMM00333554 CHEMBL2218572 Bioactive SureCN1635948

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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