CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2397
Family Name P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-1,3-dimethyl-2-oxoimidazolidine-4-carboxamide family
No. of Seeds 10 No. of Other Members 18
Family Centroid CFAMM00333577 Functional Category Bioactive
Superfamily Beta-lactamase and P2X purinoceptor 7 Binder Superfamily 2
Class Class 3485

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Mephenytoin... 5 51
Acetylcholinesterase Inhibitor Ambenonium Family 4 71
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 7
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 16 11
P2X purinoceptor 7 inhibitor (3S)-N-[[2-chloro-3-(trifluoromet... 1 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 6
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
P2X purinoceptor 7 inhibitor (2S)-N-[[2-chloro-3-(trifluoromet... 3 0
P2X purinoceptor 7 inhibitor (4S)-3-methyl-N-[[2-methyl-3-(tri... 3 0
P2X purinoceptor 7 inhibitor (3S)-N-[[2-chloro-3-(trifluoromet... 1 6
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0


External ID

Functional Category

Molecule Name

CFAMM00333597 CHEMBL2218374 Bioactive (4S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-3-ethyl-2-oxoimidazolidine-4-carboxamide
CFAMM00333576 CHEMBL2218497 Bioactive (4S)-N-[(2-chloro-4-fluorophenyl)methyl]-1,3-dimethyl-2-oxoimidazolidine-4-carboxamide
CFAMM00333582 CHEMBL2218321 Bioactive (4S)-N-[(2-chloro-3,4-difluorophenyl)methyl]-1,3-dimethyl-2-oxoimidazolidine-4-carboxamide
CFAMM00333589 CHEMBL2218265 Bioactive AGN-PC-04UWJX
CFAMM00333581 CHEMBL2218174 Bioactive (4S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-3-ethyl-1-methyl-2-oxoimidazolidine-4-carboxamide
CFAMM00333595 CHEMBL2218379 Bioactive (4S)-N-[[2-chloro-4-fluoro-3-(trifluoromethyl)phenyl]methyl]-1,3-dimethyl-2-oxoimidazolidine-4-carboxamide
CFAMM00333586 CHEMBL2218377 Bioactive (4S)-N-[(2,3-dichloro-4-fluorophenyl)methyl]-1,3-dimethyl-2-oxoimidazolidine-4-carboxamide
CFAMM00333579 CHEMBL1271604 Bioactive (4S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-3-methyl-2-oxoimidazolidine-4-carboxamide
CFAMM00333578 CHEMBL1269250 Bioactive (4S)-N-[(2,3-dichlorophenyl)methyl]-1,3-dimethyl-2-oxoimidazolidine-4-carboxamide
CFAMM00333577 CHEMBL1271548 Bioactive (4S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-1,3-dimethyl-2-oxoimidazolidine-4-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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