CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2413
Family Name Renin and Cytochrome P450 3A4 inhibitor (3R,4S)-N-[[2-chloro-5-(3-methoxypropyl)phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide family
No. of Seeds 28 No. of Other Members 3
Family Centroid CFAMM00333711 Functional Category Bioactive
Superfamily Renin and Potassium voltage-gated channel subfamily H member 2 Binder Superfamily
Class Class 3124

Cousin Family NamesSeedsMembers
Renin inhibitor (1S,5S)-7-[4-[3-(2-chloro-3,6-difluorophenoxy)... 11 16
Renin inhibitor AGN-PC-07ZC01 family 12 16
Renin inhibitor SureCN1472318 family 4 1
Renin inhibitor AGN-PC-04XLXA family 9 5
Renin and Potassium voltage-gated channel subfamily H member 2... 17 2
Renin and Cytochrome P450 3A4 inhibitor (3S,4R)-N-cyclopropyl-... 4 10
Renin inhibitor (1R,5S)-N-[(2-chlorophenyl)methyl]-7-[4-[3-[(2... 9 0
Renin inhibitor (1R,5S)-3-acetyl-N-cyclopropyl-N-[(2,3-dichlor... 11 0
Renin inhibitor SureCN5073976 family 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00333694 CHEMBL1269688 Bioactive (3R,4S)-N-[[2-chloro-5-[2-(methylamino)-2-oxoethyl]phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333707 CHEMBL1269675 Bioactive (3R,4S)-N-[[2-chloro-5-(ethylaminomethyl)phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333720 CHEMBL1269691 Bioactive (3R,4S)-N-[[2-chloro-5-[(cyclopropanecarbonylamino)methyl]phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333700 CHEMBL1269682 Bioactive (3R,4S)-N-[[5-(2-acetamidoethyl)-2-chlorophenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333713 CHEMBL1269678 Bioactive (3R,4S)-N-[[2-chloro-5-[2-(2,2-difluoroethylamino)ethyl]phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333706 CHEMBL1269676 Bioactive (3R,4S)-N-[[2-chloro-5-[2-(ethylamino)ethyl]phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333719 CHEMBL1269696 Bioactive methyl N-[[4-chloro-3-[[cyclopropyl-[(3R,4S)-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carbonyl]amino]methyl]phenyl]methyl]carbamate
CFAMM00333699 CHEMBL1269685 Bioactive (3R,4S)-N-[[2-chloro-5-[2-[[2-[(2-methylpropan-2-yl)oxy]acetyl]amino]ethyl]phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333712 CHEMBL1269679 Bioactive (3R,4S)-N-[[2-chloro-5-[(cyclopropylamino)methyl]phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333705 CHEMBL1269677 Bioactive (3R,4S)-N-[[2-chloro-5-[2-(cyclopropylamino)ethyl]phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333718 CHEMBL1269694 Bioactive methyl N-[2-[4-chloro-3-[[cyclopropyl-[(3R,4S)-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carbonyl]amino]methyl]phenyl]ethyl]carbamate
CFAMM00333698 CHEMBL1269684 Bioactive (3R,4S)-N-[[2-chloro-5-[2-(3,3,3-trifluoropropanoylamino)ethyl]phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333711 CHEMBL1269671 Bioactive (3R,4S)-N-[[2-chloro-5-(3-methoxypropyl)phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333724 CHEMBL1270761 Bioactive SureCN4147166
CFAMM00333717 CHEMBL1269695 Bioactive 2-[4-chloro-3-[[cyclopropyl-[(3R,4S)-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carbonyl]amino]methyl]phenyl]ethyl N-methylcarbamate
CFAMM00333710 CHEMBL1269672 Bioactive (3R,4S)-N-[[2-chloro-5-(2-methoxyethyl)phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333697 CHEMBL1269687 Bioactive (3R,4S)-N-[[5-(acetamidomethyl)-2-chlorophenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333723 CHEMBL1269692 Bioactive (3R,4S)-N-[[2-chloro-5-[(3,3,3-trifluoropropanoylamino)methyl]phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333703 CHEMBL1269681 Bioactive (3R,4S)-N-[[2-chloro-5-[(2,2-difluoroethylamino)methyl]phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333696 CHEMBL1269686 Bioactive (3R,4S)-N-[[2-chloro-5-[2-(ethylamino)-2-oxoethyl]phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333709 CHEMBL1269673 Bioactive (3R,4S)-N-[[2-chloro-5-[2-(methylamino)ethyl]phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333722 CHEMBL1269693 Bioactive [4-chloro-3-[[cyclopropyl-[(3R,4S)-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carbonyl]amino]methyl]phenyl]methyl N-methylcarbamate
CFAMM00333702 CHEMBL1269680 Bioactive (3R,4S)-N-[[2-chloro-5-[(2-fluoroethylamino)methyl]phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333715 CHEMBL1269699 Bioactive (3S,4R)-N-[[2-chloro-5-(2-methoxyethyl)phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]-4-hydroxypiperidine-3-carboxamide
CFAMM00333695 CHEMBL1269689 Bioactive (3R,4S)-N-[[2-chloro-5-[(propanoylamino)methyl]phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333708 CHEMBL1269674 Bioactive (3R,4S)-N-[[2-chloro-5-(methylaminomethyl)phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333721 CHEMBL1269690 Bioactive (3R,4S)-N-[[2-chloro-5-[2-(cyclopropylamino)-2-oxoethyl]phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide
CFAMM00333701 CHEMBL1269683 Bioactive (3R,4S)-N-[[2-chloro-5-[3-(methylamino)-3-oxopropyl]phenyl]methyl]-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]piperidine-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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