CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2426
Family Name Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-6-[(2-fluorophenyl)methylamino]-N-hydroxyhexanamide family
No. of Seeds 11 No. of Other Members 8
Family Centroid CFAMM00333866 Functional Category Bioactive
Superfamily Lethal factor Binder Superfamily
Class Class 3354

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Motilin receptor Ligand GSK962040 Family 30 457
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Cholecystokinin receptor type A Ligand L-708474 Family 14 82
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Androgen receptor Ligand YM-175735 Family 30 129
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Transient receptor potential cation channel subfamily V member... 1 5
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 1 1
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 12 4
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(3-cyanophe... 7 5
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Vasopressin V1a receptor ligand AGN-PC-074VJP family 3 1
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 2 2
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 6 3
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 5 2
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
Lethal factor inhibitor (2R)-6-[(4-chlorophenyl)methylamino]-2... 3 0
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 1 0
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 2 1
Mitogen-activated protein kinase 1 and M17 leucyl aminopeptida... 1 21
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 10 0
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 6 5
Hypoxia-inducible factor 1-alpha and Ubiquitin carboxyl-termin... 1 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
Peptide deformylase inhibitor (2R)-2-(cyclopentylmethyl)-3-[fo... 11 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 6
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 1
Cathepsin K and Cathepsin L1 inhibitor 1-[(2S)-1-[[cyano(methy... 2 1
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 0
Ectonucleotide pyrophosphatase/phosphodiesterase family member... 1 1
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
C-C chemokine receptor type 3 and Sodium-dependent serotonin t... 12 2
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
C-C chemokine receptor type 2 ligand N-[2-[[(2S,3S)-1-[(2,4-di... 13 8
C-C chemokine receptor type 2 ligand N-[3-amino-5-(trifluorome... 4 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
ALK tyrosine kinase receptor ligand 4-fluoro-N-[6-(piperidin-1... 10 7
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 4
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 1 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 7 12
Substance-P receptor ligand N-[[3,5-bis(trifluoromethyl)phenyl... 1 0
Growth hormone secretagogue receptor type 1 ligand SureCN77944... 1 2
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 7 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 5
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Collagenase 3 and Interstitial collagenase inhibitor (2R,3S)-N... 1 0
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(1-hydroxy-3... 3 0
Neutrophil elastase inhibitor 1-[(2S)-3-methyl-2-[(4-nitrobenz... 1 1
Microbial collagenase inhibitor AGN-PC-00F17U family 1 1
Peptide deformylase inhibitor N-[(2R,4S)-2-butyl-5-methyl-3-ox... 2 0
Aminopeptidase N inhibitor (2S)-2-[(2-chlorophenyl)carbamoylam... 1 1
Interstitial collagenase and Matrix metalloproteinase-9 inhibi... 2 2
Substance-P receptor ligand (2S)-2-N-[2-[(3,5-dimethylphenyl)m... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00333864 CHEMBL1270304 Bioactive (2R)-2-(4-fluoro-3,5-dimethylanilino)-N-hydroxy-6-[(4-nitrophenyl)methylamino]hexanamide
CFAMM00333878 CHEMBL1270211 Bioactive (2R)-2-(4-fluoro-3,5-dimethylanilino)-N-hydroxy-6-[[4-(trifluoromethyl)phenyl]methylamino]hexanamide
CFAMM00333877 CHEMBL1760326 Bioactive (2R)-2-(4-fluoro-3-methylanilino)-6-[(4-fluoro-3-methylphenyl)methylamino]-N-hydroxyhexanamide
CFAMM00333869 CHEMBL1271312 Bioactive 4-fluoro-N-[(5R)-5-(4-fluoro-3,5-dimethylanilino)-6-(hydroxyamino)-6-oxohexyl]-3-methylbenzamide
CFAMM00333862 CHEMBL1270305 Bioactive (2R)-6-[(4-tert-butylphenyl)methylamino]-2-(4-fluoro-3,5-dimethylanilino)-N-hydroxyhexanamide
CFAMM00333876 CHEMBL1269993 Bioactive (2R)-2-(4-fluoro-3,5-dimethylanilino)-6-[(3-fluorophenyl)methylamino]-N-hydroxyhexanamide
CFAMM00333867 CHEMBL1269994 Bioactive (2R)-2-(4-fluoro-3,5-dimethylanilino)-6-[(4-fluorophenyl)methylamino]-N-hydroxyhexanamide
CFAMM00333866 CHEMBL1269887 Bioactive (2R)-2-(4-fluoro-3,5-dimethylanilino)-6-[(2-fluorophenyl)methylamino]-N-hydroxyhexanamide
CFAMM00333872 CHEMBL1271420 Bioactive (2R)-2-(4-fluoro-3,5-dimethylanilino)-6-[(4-fluoro-3-methylphenyl)methylamino]-N-hydroxyhexanamide
CFAMM00333865 CHEMBL1269886 Bioactive (2R)-2-(4-fluoro-3,5-dimethylanilino)-6-[(4-fluoro-3-methylphenyl)carbamoylamino]-N-hydroxyhexanamide
CFAMM00333879 CHEMBL1270103 Bioactive (2R)-2-(4-fluoro-3,5-dimethylanilino)-N-hydroxy-6-[(4-methylphenyl)methylamino]hexanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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