CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2429
Family Name Adenosine receptor A2a ligand AGN-PC-01LVXW family
No. of Seeds 2 No. of Other Members 25
Family Centroid CFAMM00114238 Functional Category Bioactive
Superfamily Adenosine receptor A2a and Protein farnesyltransferase subunit beta Binder Superfamily
Class Class 1238

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Type-1 angiotensin II receptor Ligand Telmisartan Family 4 181
Tubulin beta chain Inhibitor Mebendazole Family 12 84
Histamine H1 receptor Ligand Mizolastine Family 14 603
Prothrombin Inhibitor Dabigatran Family 7 182
BIBT986 family 7 96
SB989 family 17 91
CC-486 family 7 103
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Telomerase reverse transcriptase Inhibitor NSC-745794 Family 3 1
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 0
Cannabinoid receptor 2 ligand AGN-PC-080WIY family 1 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Prelamin-A/C and Niemann-Pick C1 protein inhibitor CHEMBL13592... 1 16
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 1
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
C-C chemokine receptor type 5 ligand [4-[2-[3-(2-ethylbenzimid... 5 12
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Histamine H3 receptor ligand SureCN2878688 family 8 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Type-1 angiotensin II receptor and Type-1A angiotensin II rece... 3 0
Cdc2-related kinase inhibitor N-[6-(3,5-dimethylphenyl)-1-meth... 1 0
ALK tyrosine kinase receptor ligand N-[6-[[4-(2-hydroxypropan-... 2 0
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 2 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Melanocortin receptor 4 ligand AGN-PC-076ANF family 1 0
Melanocortin receptor 4 ligand AGN-PC-076AMT family 2 9
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 10 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Disintegrin and metalloproteinase domain-containing protein 17... 3 0
Disintegrin and metalloproteinase domain-containing protein 17... 10 4
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 3
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Glucagon receptor ligand SureCN2666184 family 7 2
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Melanin-concentrating hormone receptor 1 ligand SureCN3832854 ... 3 2
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Dipeptidyl peptidase 4 inhibitor SureCN5776796 family 1 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Neuropeptide Y receptor type 5 ligand SureCN8149543 family 1 0
Reverse transcriptase/RNaseH inhibitor AC1LAPCJ family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00333934 CHEMBL485591 Bioactive AGN-PC-077R4K

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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