CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM24365
Family Name Sodium- and chloride-dependent GABA transporter 1 inhibitor (3R)-1-[(E)-4-(2-fluorophenyl)-4-(2-methylphenyl)but-3-enyl]piperidine-3-carboxylic acid family
No. of Seeds 17 No. of Other Members 43
Family Centroid CFAMM00469589 Functional Category Bioactive
Superfamily Sodium- and chloride-dependent GABA transporter 1 Binder Superfamily 2
Class Class 1358

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Alpha-2 adrenergic receptor ligand opiate Meperidine Family 13 76
Muscarinic acetylcholine receptor Ligand Cyclopentolate Family 10 11
Sodium-dependent dopamine transporter Inhibitor Ioflupane I-12... 130 181
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
Sphingosine 1-phosphate receptor 1 Ligand 1-(4-nonylbenzyl)aze... 2 6
5-hydroxytryptamine receptor 2B and 5-hydroxytryptamine recept... 4 16
Histamine H1 receptor and 5-hydroxytryptamine receptor 2C liga... 3 6
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Sodium- and chloride-dependent GABA transporter 1 inhibitor Su... 8 8
Sodium- and chloride-dependent GABA transporter 1 inhibitor (3... 2 0
Sodium- and chloride-dependent GABA transporter 1 and Sodium- ... 5 4
Sodium- and chloride-dependent GABA transporter 1 inhibitor Su... 3 0
Sodium- and chloride-dependent GABA transporter 1 inhibitor Su... 10 3
Sodium- and chloride-dependent GABA transporter 1 inhibitor (3... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00469645 CHEMBL543557 Bioactive SKF 89976A hydrochloride
CFAMM00469625 CHEMBL1642400 Bioactive (3R)-1-[(E)-4-(4-fluoro-2-methylphenyl)-4-(2-fluorophenyl)but-3-enyl]piperidine-3-carboxylic acid
CFAMM00469638 CHEMBL1642401 Bioactive (3R)-1-[(E)-4-(4-fluoro-2-methylphenyl)-4-[2-(trifluoromethyl)phenyl]but-3-enyl]piperidine-3-carboxylic acid
CFAMM00469597 CHEMBL1642367 Bioactive (3R)-1-[(E)-4-(2-methylphenyl)-4-phenylbut-3-enyl]piperidine-3-carboxylic acid
CFAMM00469624 CHEMBL1642378 Bioactive (3R)-1-[(Z)-4-(2-methylphenyl)-4-phenylbut-3-enyl]piperidine-3-carboxylic acid
CFAMM00469630 CHEMBL1642377 Bioactive (3R)-1-[(Z)-4-phenyl-4-[2-(trifluoromethyl)phenyl]but-3-enyl]piperidine-3-carboxylic acid
CFAMM00469623 CHEMBL1642379 Bioactive (3R)-1-[(Z)-4-(2-ethylphenyl)-4-phenylbut-3-enyl]piperidine-3-carboxylic acid
CFAMM00469589 CHEMBL1641613 Bioactive (3R)-1-[(E)-4-(2-fluorophenyl)-4-(2-methylphenyl)but-3-enyl]piperidine-3-carboxylic acid
CFAMM00469629 CHEMBL1642374 Bioactive (3R)-1-[(Z)-4-(2-fluorophenyl)-4-phenylbut-3-enyl]piperidine-3-carboxylic acid
CFAMM00469642 CHEMBL1642395 Bioactive (3R)-1-[(E)-4-(2-ethylphenyl)-4-(2-fluorophenyl)but-3-enyl]piperidine-3-carboxylic acid
CFAMM00469609 CHEMBL1642387 Bioactive (3R)-1-[(Z)-4-(2-ethylphenyl)-4-(2-fluorophenyl)but-3-enyl]piperidine-3-carboxylic acid
CFAMM00469608 CHEMBL1642386 Bioactive (3R)-1-[(Z)-4-(2-fluorophenyl)-4-(2-methylphenyl)but-3-enyl]piperidine-3-carboxylic acid
CFAMM00469614 CHEMBL1642388 Bioactive (3R)-1-[4,4-bis(2-fluorophenyl)but-3-enyl]piperidine-3-carboxylic acid
CFAMM00469607 CHEMBL1642385 Bioactive (3R)-1-[(Z)-4-(2,6-dimethylphenyl)-4-phenylbut-3-enyl]piperidine-3-carboxylic acid
CFAMM00469646 CHEMBL1642394 Bioactive (3R)-1-[4,4-bis(2-methylphenyl)but-3-enyl]piperidine-3-carboxylic acid
CFAMM00469606 CHEMBL1642384 Bioactive (3R)-1-[(Z)-4-(4-fluoro-2-methylphenyl)-4-phenylbut-3-enyl]piperidine-3-carboxylic acid
CFAMM00469619 CHEMBL77626 Bioactive SKF-89976

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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