CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2440
Family Name Coagulation factor X and Prothrombin inhibitor SureCN763988 family
No. of Seeds 31 No. of Other Members 86
Family Centroid CFAMM00334189 Functional Category Bioactive
Superfamily Coagulation factor X and Prothrombin Binder Superfamily 7
Class Class 1056

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Reverse transcriptase Inhibitor IDX899 Family 2 118
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Pyruvate kinase PKLR and Pyruvate kinase PKM inhibitor AGN-PC-... 17 23
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1367658 ... 1 7
Glycogen phosphorylase, liver form inhibitor 2,3-dichloro-N-[(... 2 14
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Coagulation factor X inhibitor N-[5-carbamoyl-2-[[(5-chlorothi... 8 8
Coagulation factor X inhibitor AGN-PC-0A9SP0 family 6 5
Coagulation factor X inhibitor 2-[4-[(5-chloro-1H-indole-2-car... 4 0
Coagulation factor X inhibitor 2-carboxyindole 24 family 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 2 9
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Serine/threonine-protein kinase Chk1 inhibitor 2-(1H-indol-5-y... 2 2
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 5 5
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 4 4
MAP kinase-activated protein kinase 2 inhibitor 2-[(4,4-dimeth... 11 11
Pol polyprotein and Reverse transcriptase/RNaseH inhibitor CSI... 1 5
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
Glycogen phosphorylase, liver form inhibitor SureCN5630210 family 2 0
Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Coagulation factor X inhibitor SureCN1251046 family 3 0
Coagulation factor X inhibitor SureCN1322298 family 2 1
Coagulation factor X inhibitor N-[(1R,2S,5S)-2-[(5-bromo-1H-in... 1 1
Coagulation factor X inhibitor SureCN1253902 family 2 0
Histamine H4 receptor ligand SureCN605081 family 1 0
Coagulation factor X inhibitor 5-Chloro-N-{(3s)-1-[(1s)-1-Meth... 1 1
(2S)-1-[(2S)-2-[(5-chloro-1-methylindole-2-carbonyl)amino]-4-m... 1 0


External ID

Functional Category

Molecule Name

CFAMM00334178 CHEMBL403904 Bioactive N-[(3R,4S)-4-[(5-chloro-1H-indole-2-carbonyl)amino]-1-(ethylcarbamoyl)piperidin-3-yl]-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carboxamide
CFAMM00334250 CHEMBL271011 Bioactive N-[(3R,4S)-1-(tert-butylcarbamoyl)-4-[(5-chloro-1H-indole-2-carbonyl)amino]piperidin-3-yl]-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carboxamide
CFAMM00334165 CHEMBL271316 Bioactive tert-butyl 4-[(5-chloro-1H-indole-2-carbonyl)amino]-3-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]piperidine-1-carboxylate
CFAMM00334204 CHEMBL474459 Bioactive SureCN1253841
CFAMM00334153 CHEMBL516195 Bioactive SureCN763909
CFAMM00334230 CHEMBL430037 Bioactive SureCN3199852
CFAMM00334210 CHEMBL514798 Bioactive SureCN1321937
CFAMM00334249 CHEMBL606154 Bioactive SureCN1251245
CFAMM00334236 CHEMBL257080 Bioactive N-[(3R,4S)-4-[(5-chloro-1H-indole-2-carbonyl)amino]-1-(2-hydroxyacetyl)piperidin-3-yl]-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carboxamide
CFAMM00334203 CHEMBL1761619 Bioactive AGN-PC-0A9S23
CFAMM00334262 CHEMBL271895 Bioactive N-[(3R,4S)-4-[(5-chloro-1H-indole-2-carbonyl)amino]-1-propanoylpiperidin-3-yl]-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carboxamide
CFAMM00334229 CHEMBL473243 Bioactive SureCN1251188
CFAMM00334242 CHEMBL479662 Bioactive N-[(1R,2S,5S)-5-acetyl-2-[(5-chloro-1H-indole-2-carbonyl)amino]cyclohexyl]-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carboxamide
CFAMM00334158 CHEMBL473856 Bioactive SureCN11888216
CFAMM00334189 CHEMBL479863 Bioactive SureCN763988
CFAMM00334228 CHEMBL258328 Bioactive ethyl 4-[(5-chloro-1H-indole-2-carbonyl)amino]-3-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]piperidine-1-carboxylate
CFAMM00334241 CHEMBL256814 Bioactive N-[(3R,4S)-4-[(5-chloro-1H-indole-2-carbonyl)amino]-1-(2-methylpropanoyl)piperidin-3-yl]-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carboxamide
CFAMM00334169 CHEMBL1270159 Bioactive SureCN1251034
CFAMM00334188 CHEMBL508906 Bioactive SureCN12631946
CFAMM00334234 CHEMBL402343 Bioactive N-[(3R,4S)-4-[(5-chloro-1H-indole-2-carbonyl)amino]-1-(2-methoxyacetyl)piperidin-3-yl]-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carboxamide
CFAMM00334247 CHEMBL480637 Bioactive SureCN765289
CFAMM00334201 CHEMBL1761615 Bioactive AGN-PC-0A9QPQ
CFAMM00334240 CHEMBL515895 Bioactive SureCN10279900
CFAMM00334174 CHEMBL595509 Bioactive SureCN1252763
CFAMM00334246 CHEMBL516922 Bioactive SureCN7269165
CFAMM00334232 CHEMBL595725 Bioactive N-[(1R,2S,5S)-2-[(5-chloro-3-formyl-1H-indole-2-carbonyl)amino]-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carboxamide
CFAMM00334173 CHEMBL604268 Bioactive SureCN765308
CFAMM00334186 CHEMBL595710 Bioactive SureCN12036288
CFAMM00334264 CHEMBL515569 Bioactive SureCN10279614
CFAMM00334218 CHEMBL594121 Bioactive SureCN1252841
CFAMM00334231 CHEMBL256801 Bioactive SureCN3204892

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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