CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM24413
Family Name Serine/threonine-protein kinase Chk2 inhibitor (6E)-4-fluoro-6-[4-[[(3S,4R)-4-(hydroxymethyl)pyrrolidin-3-yl]amino]-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one family
No. of Seeds 3 No. of Other Members 6
Family Centroid CFAMM00469833 Functional Category Bioactive
Superfamily cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhibited 3',5'-cyclic phosphodiesterase A Binder Superfamily
Class Class 976

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Tyrosine kinase Inhibitor PKI166 Family 17 198
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Adenosine receptor A1 and Adenosine receptor A2a Ligand GW-328... 26 94
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 21 57
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Adenosine receptor A1 and Adenosine receptor A2a ligand NSC658... 8 54
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 3 6
Adenosine receptor A3 and Adenosine receptor A2a ligand 4-(5-b... 2 5
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Adenosine receptor A1 and Adenosine receptor A2a ligand (6E)-6... 2 2
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Methionine--tRNA ligase, cytoplasmic and Methionine--tRNA liga... 8 6
Methionine--tRNA ligase inhibitor 2-({3-[(3,5-Dichlorobenzyl)a... 5 7
Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Proto-oncogene tyrosine-protein kinase Src and Epidermal growt... 9 9
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 6
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 4 11
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
Coagulation factor VII inhibitor [3-[(5E)-5-(5-carbamimidoyl-1... 3 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 11 1
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Cationic trypsin and Prothrombin inhibitor 2-ketobenzothiazole... 1 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 inhibi... 9 4
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 2 8


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00469836 CHEMBL1650122 Bioactive (6E)-6-[7-(3-hydroxypropyl)-4-[[(3S)-pyrrolidin-3-yl]amino]-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one
CFAMM00469833 CHEMBL1650056 Bioactive (6E)-4-fluoro-6-[4-[[(3S,4R)-4-(hydroxymethyl)pyrrolidin-3-yl]amino]-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one
CFAMM00469832 CHEMBL1650115 Bioactive (6E)-4-fluoro-6-[4-[[(3S,5R)-5-(hydroxymethyl)pyrrolidin-3-yl]amino]-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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