CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2447
Family Name Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC-088JBL family
No. of Seeds 4 No. of Other Members 21
Family Centroid CFAMM00334305 Functional Category Bioactive
Superfamily Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protein kinase Src Binder Superfamily
Class Class 1340

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Setipiprant family 5 118
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 3-phen... 10 27
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Aurora kinase A and Aurora kinase B inhibitor SureCN3802769 fa... 2 20
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Prelamin-A/C and Pyruvate kinase PKM inhibitor CHEMBL1481187 f... 1 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Motilin receptor ligand SureCN2768052 family 3 0
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Acetylcholinesterase inhibitor N-[6-[4-[(6-chloro-1,2,3,4-tetr... 9 0
Hepatocyte growth factor receptor and Protein-tyrosine kinase ... 2 15
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protei... 7 18
Coagulation factor X and Trypsin-1 inhibitor SureCN6166035 family 1 2
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Caspase-3 inhibitor 2-[8-morpholin-4-ylsulfonyl-1,3-dioxo-4-[(... 2 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00334305 CHEMBL1270341 Bioactive AGN-PC-088JBL
CFAMM00334323 CHEMBL1270438 Bioactive AGN-PC-09M6FG
CFAMM00334329 CHEMBL1270531 Bioactive AGN-PC-09M8R5
CFAMM00334328 CHEMBL1270532 Bioactive AGN-PC-09M812

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26825 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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