CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2448
Family Name Prothrombin inhibitor SureCN7341151 family
No. of Seeds 6 No. of Other Members 7
Family Centroid CFAMM00334337 Functional Category Bioactive
Superfamily Prothrombin and Coagulation factor X Binder Superfamily 5
Class Class 1271

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Neuropeptide Y receptor type 1 Ligand BIBO3304 Family 4 69
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha... 19 95
Prothrombin Inhibitor Efegatran Family 9 47
Prothrombin Inhibitor LB30812 Family 12 36
Prothrombin Inhibitor Ppack Family 5 4
Prothrombin Inhibitor D-leucyl-n-(4-carbamimidoylbenzyl)-l-pro... 13 44
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Suppressor of tumorigenicity 14 protein Inhibitor 3-tapap Family 15 39
Melanocortin receptor 4 and Substance-K receptor Ligand Hoo-ph... 3 19
Chymase Inhibitor Chymostatin Family 2 3
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Trypsin Inhibitor P1 Argininal Derivative Family 13 36
Coagulation factor X inhibitor (6S,8aS)-2-benzhydrylsulfonyl-N... 5 5
Plasminogen and Plasma kallikrein inhibitor CHEMBL2016864 family 9 16
Prothrombin and Suppressor of tumorigenicity 14 protein inhibi... 5 8
Prothrombin and Cationic trypsin inhibitor 2-[butyl-[(2S)-4-[[... 7 32
Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4... 7 24
Prothrombin inhibitor (2S)-N-[4-(2-amino-2-iminoethyl)cyclohex... 2 0
Prothrombin inhibitor bms-189090 family 1 8
Trypsin-1 and Urokinase-type plasminogen activator inhibitor (... 3 9
Coagulation factor X inhibitor (6S,8aS)-N-[(1-carbamimidoylpip... 6 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2S... 16 24
Prothrombin inhibitor ethyl (3S)-3-(benzylsulfonylamino)-1-[2-... 3 1
Prothrombin and Coagulation factor X inhibitor tert-butyl (4R)... 1 0
Prothrombin and Transmembrane protease serine 11D inhibitor be... 1 4
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Menin inhibitor CHEMBL2314816 family 2 6
Neutrophil elastase inhibitor SureCN6619034 family 1 8
Collagenase 3 and Macrophage metalloelastase inhibitor (2R)-N-... 1 2
Cationic trypsin and Prothrombin inhibitor (3S,6S)-6-amino-6-b... 4 2
Prothrombin and Trypsin-1 inhibitor 2-[3-(benzylsulfonylamino)... 4 3
Neutrophil elastase inhibitor 1-[(2S)-3-methyl-2-(naphthalen-2... 3 1
Coagulation factor X inhibitor ethyl 2-[[(3S)-3-[[2-[[(2R)-2-(... 4 0
Prothrombin inhibitor 2-[(3R)-3-amino-3-benzyl-2-oxopiperidin-... 3 0
Prothrombin inhibitor methyl (3S)-3-[[(6S,8aS)-2-benzylsulfony... 5 1
Growth hormone secretagogue receptor type 1 ligand [(3S)-3-ami... 2 6
Genome polyprotein inhibitor Benzoyl-KKR-H family 1 1
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047569... 1 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00334333 CHEMBL141424 Bioactive 2-[(3S)-3-(benzylsulfonylamino)-2-oxopiperidin-1-yl]-N-[(2S)-1-[(3S)-1-carbamimidoylpiperidin-3-yl]-3-oxopropan-2-yl]acetamide
CFAMM00334340 CHEMBL356065 Bioactive SureCN7346744
CFAMM00334332 CHEMBL424316 Bioactive (2S)-1-[(2R)-2-(benzylsulfonylamino)-3-phenylpropanoyl]-N-[[1-[(E)-N'-hydroxycarbamimidoyl]piperidin-4-yl]methyl]pyrrolidine-2-carboxamide
CFAMM00334339 CHEMBL1270358 Bioactive (2R)-2-(benzylsulfonylamino)-3-(1-carbamimidoylpiperidin-4-yl)-N-[2-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]propanamide
CFAMM00334337 CHEMBL148208 Bioactive SureCN7341151
CFAMM00334343 CHEMBL342914 Bioactive 2-[(3S)-3-(benzylsulfonylamino)-2-oxoazepan-1-yl]-N-[(2S)-1-(1-carbamimidoylpiperidin-3-yl)-3-oxopropan-2-yl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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