CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2461
Family Name Coagulation factor X inhibitor AGN-PC-075AY8 family
No. of Seeds 28 No. of Other Members 21
Family Centroid CFAMM00334430 Functional Category Bioactive
Superfamily Coagulation factor X and C-X-C chemokine receptor type 3 Binder Superfamily
Class Class 2337

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Transient receptor potential cation channel subfamily V member... 16 295
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Casein kinase II subunit alpha Inhibitor CX-4945 Family 1 7
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Class II cytokine receptor Ligand IL-10 Family 7 45
Tubulin beta chain Inhibitor 2-(3-chloro-phenyl)-1h-[1,8]napht... 3 13
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Metabotropic glutamate receptor 5 Ligand 3-chloro-n-(6-chlorop... 2 5
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
ALK tyrosine kinase receptor ligand SureCN1600195 family 1 1
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Serine/threonine-protein kinase Chk1 inhibitor SureCN13010134 ... 7 29
Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Cellular tumor antigen p53 inhibitor CHEMBL1551403 family 1 0
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Coagulation factor X and Kallikrein-1 inhibitor SureCN890858 f... 5 6
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Coagulation factor X inhibitor AGN-PC-078Y3A family 4 1
Nicotinamide phosphoribosyltransferase inhibitor 4-[[(7-chloro... 1 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Mitogen-activated protein kinase 14 inhibitor SureCN3305171 fa... 1 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(2-amino-6... 13 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[3-(4-chlorop... 4 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
ALK tyrosine kinase receptor and Insulin receptor ligand 2-[[5... 1 0
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Substance-P receptor ligand Netupitant family 5 2
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 0
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 2 11
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Tyrosine-protein kinase receptor TYRO3 and Mitogen-activated p... 3 7
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Coagulation factor X inhibitor 5-bromo-N-(5-chloropyridin-2-yl... 1 1
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 1
Glutamate receptor 1 and Glutamate receptor 2 ligand cp-465022... 1 6
Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbu... 12 21
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[4-oxo-3-(4-p... 2 1
Coagulation factor X inhibitor N-[2-[(5-chloropyridin-2-yl)sul... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Cannabinoid receptor 2 ligand N-isoquinolin-1-yl-4-methyl-3-pi... 1 0
Macrophage colony-stimulating factor 1 receptor ligand N-[3-[(... 5 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
Mitogen-activated protein kinase 14 inhibitor AGN-PC-077MAQ fa... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 3
C-C chemokine receptor type 3 ligand 4-[[2-(4-chlorophenyl)eth... 2 1
P2X purinoceptor 7 inhibitor 1-[3-[4-chloro-3-(cycloheptylmeth... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [2-(a... 1 2
Potassium voltage-gated channel subfamily KQT member 3 and Pot... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00334436 CHEMBL177564 Bioactive AGN-PC-075AVA
CFAMM00334449 CHEMBL367386 Bioactive AGN-PC-075A6L
CFAMM00334468 CHEMBL444809 Bioactive AGN-PC-0759ZD
CFAMM00334455 CHEMBL427479 Bioactive AGN-PC-075A7C
CFAMM00334461 CHEMBL176136 Bioactive 5-chloro-N-(5-chloropyridin-2-yl)-2-[[4-[2-(N,N-dimethylcarbamimidoyl)phenyl]benzoyl]amino]benzamide
CFAMM00334441 CHEMBL368089 Bioactive AGN-PC-075AWN
CFAMM00334467 CHEMBL176830 Bioactive AGN-PC-075ARJ
CFAMM00334460 CHEMBL368544 Bioactive AGN-PC-0759WQ
CFAMM00334434 CHEMBL171854 Bioactive 2-[[4-[2-[(1-aminoethylideneamino)methyl]phenyl]benzoyl]amino]-5-chloro-N-(5-chloropyridin-2-yl)benzamide
CFAMM00334473 CHEMBL369130 Bioactive AGN-PC-075A7X
CFAMM00334466 CHEMBL355573 Bioactive AGN-PC-075AWR
CFAMM00334433 CHEMBL368984 Bioactive AGN-PC-075AX5
CFAMM00334472 CHEMBL367451 Bioactive AGN-PC-0759WO
CFAMM00334426 CHEMBL1270651 Bioactive AGN-PC-09M4ME
CFAMM00334465 CHEMBL176866 Bioactive AGN-PC-075AGZ
CFAMM00334432 CHEMBL362229 Bioactive AGN-PC-075ASX
CFAMM00334445 CHEMBL177652 Bioactive AGN-PC-075AM6
CFAMM00334458 CHEMBL368411 Bioactive AGN-PC-075A4E
CFAMM00334471 CHEMBL174815 Bioactive AGN-PC-075AHP
CFAMM00334438 CHEMBL222012 Bioactive 1-[4-[[4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]phenyl]carbamoyl]benzenecarboximidoyl]piperidine-4-carboxylic acid
CFAMM00334464 CHEMBL425142 Bioactive AGN-PC-075A7D
CFAMM00334457 CHEMBL174330 Bioactive AGN-PC-075A6M
CFAMM00334470 CHEMBL367644 Bioactive AGN-PC-075A6N
CFAMM00334463 CHEMBL173878 Bioactive AGN-PC-075AB8
CFAMM00334430 CHEMBL366862 Bioactive AGN-PC-075AY8
CFAMM00334443 CHEMBL221956 Bioactive 1-[2-[[4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]phenyl]carbamoyl]-5-(N,N-dimethylcarbamimidoyl)phenyl]piperidine-4-carboxylic acid
CFAMM00334456 CHEMBL174335 Bioactive AGN-PC-075A3Q
CFAMM00334469 CHEMBL368095 Bioactive AGN-PC-0759XL

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27254 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543