CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM24653
Family Name TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-methylpyridin-2-yl)-4-quinoxalin-6-ylpyrazol-1-yl]ethanethioamide family
No. of Seeds 4 No. of Other Members 5
Family Centroid CFAMM00470902 Functional Category Bioactive
Superfamily Protein kinase C theta type and Protein kinase C delta type Binder Superfamily
Class Class 1666

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Hepatocyte growth factor receptor Ligand MK-8033 Family 19 42
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
PF-4217903 family 14 65
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
Metabotropic glutamate receptor 5 Ligand 3-(3-pyridin-2-yl-pyr... 4 24
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Cytochrome P450 3A4 Inhibitor 5-(2-phenethylpiperazin-1-yl)-1h... 12 35
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 6
Acetylcholinesterase and Cholinesterase inhibitor 3,8-DIAMINO-... 2 3
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Tyrosine-protein kinase ITK/TSK inhibitor (3Z)-3-(6-methylindo... 2 40
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 6 4
Transient receptor potential cation channel subfamily V member... 1 0
TGF-beta receptor type-1 ligand 6-bromo-4-(2-(6-methylpyridin-... 1 3
TGF-beta receptor type-1 ligand SureCN373106 family 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00470903 CHEMBL1766441 Bioactive AGN-PC-09LPLP
CFAMM00470902 CHEMBL1824442 Bioactive N-(3-cyanophenyl)-2-[3-(6-methylpyridin-2-yl)-4-quinoxalin-6-ylpyrazol-1-yl]ethanethioamide
CFAMM00470901 CHEMBL1824440 Bioactive 2-[3-(6-methylpyridin-2-yl)-4-quinoxalin-6-ylpyrazol-1-yl]-N-phenylethanethioamide
CFAMM00470905 CHEMBL1766454 Bioactive AGN-PC-09LPNE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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