CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM24661
Family Name A disintegrin and metalloproteinase with thrombospondin motifs 5 and Matrix metalloproteinase-14 inhibitor (1S,2R,3R)-1-[(8-chloro-3,4-dihydro-1H-pyrazino[1,2-a]indol-2-yl)sulfonylamino]-2-methyl-3-phenylcyclopropane-1-carboxylic acid family
No. of Seeds 2 No. of Other Members 12
Family Centroid CFAMM00470945 Functional Category Bioactive with Natural Product
Superfamily A disintegrin and metalloproteinase with thrombospondin motifs 5 and Matrix metalloproteinase-14 Binder Superfamily
Class Class 3322

Cousin Family NamesSeedsMembers
Alpha-2 adrenergic receptor Ligand Yohimbine Family 7 52
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Substance-P receptor Ligand GSK424887 Family 8 184
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Endothelin B receptor Ligand IRL-2500 Family 34 87
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
Prostaglandin D2 receptor 2 ligand SureCN2189431 family 7 1
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 48


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00470953 CHEMBL1767012 Bioactive (1S,2R,3R)-1-[(7-fluoro-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)sulfonylamino]-2-methyl-3-phenylcyclopropane-1-carboxylic acid
CFAMM00470945 CHEMBL1766919 Bioactive (1S,2R,3R)-1-[(8-chloro-3,4-dihydro-1H-pyrazino[1,2-a]indol-2-yl)sulfonylamino]-2-methyl-3-phenylcyclopropane-1-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27521 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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