CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN13789769 family
No. of Seeds 6 No. of Other Members 16
Family Centroid CFAMM00309437 Functional Category Bioactive with Natural Product
Superfamily cGMP-specific 3',5'-cyclic phosphodiesterase and Adenosine receptor A2b Binder Superfamily
Class Class 253

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Adenosine receptor A2a Ligand KW-6002 Family 18 195
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Arof... 3 196
Dipeptidyl peptidase 4 Inhibitor SSR-162369 Family 8 27
GP-531 family 1 33
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
Adenosine receptor A1 and Adenosine receptor A2b Ligand PSB-11... 34 26
Herpes simplex virus type 1 thymidine kinase Inhibitor 9-(4-hy... 2 13
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Adenosine receptor A2a Ligand (e,e)-8-(4-phenylbutadien-1-yl)c... 11 43
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SCH-577... 9 29
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 17 3
Adenosine receptor A1 and Adenosine receptor A2b ligand 3-meth... 7 19
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-[4-[... 12 15
Dipeptidyl peptidase 4 inhibitor Xanthine Analogue 4 family 1 4
Dipeptidyl peptidase 4 inhibitor AGN-PC-046QKE family 3 5
Vascular endothelial growth factor receptor 2 ligand AC1LLCDM ... 1 2
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
Prelamin-A/C inhibitor CHEMBL1501476 family 1 2
Prelamin-A/C inhibitor CHEMBL1503535 family 1 0
Cellular tumor antigen p53 and Thyrotropin receptor ligand CHE... 1 5
Survival motor neuron protein and Microtubule-associated prote... 2 14
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
C-X-C chemokine receptor type 3 ligand 3-amino-6-chloro-5-[(3S... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 13 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 10 0
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 2 0
Sodium- and chloride-dependent glycine transporter 1 and Potas... 14 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
P2X purinoceptor 7 inhibitor (7R)-1-[(3,4-difluorophenyl)methy... 1 0


External ID

Functional Category

Molecule Name

CFAMM00309429 CHEMBL106153 Bioactive SureCN13789905
CFAMM00309441 CHEMBL322272 Bioactive SureCN13789983
CFAMM00309434 CHEMBL106480 Bioactive SureCN13789826
CFAMM00309440 CHEMBL108491 Bioactive 8-(cyclohexylamino)-1,3-diethyl-7-[(3-fluoro-4-hydroxyphenyl)methyl]purine-2,6-dione
CFAMM00309439 CHEMBL324645 Bioactive 8-(cyclopentylamino)-1,3-diethyl-7-[(3-fluoro-4-hydroxyphenyl)methyl]purine-2,6-dione
CFAMM00309437 CHEMBL107156 Bioactive SureCN13789769

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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