CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM24813
Family Name Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)-2-[(2S,3S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-methylpentanoyl]-7-[2-(hydroxyamino)-2-oxoethoxy]-N-(4-methoxyphenyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide;hydrochloride family
No. of Seeds 4 No. of Other Members 16
Family Centroid CFAMM00471870 Functional Category Bioactive
Superfamily Disintegrin and Lethal factor Binder Superfamily
Class Class 1560

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Substance-K receptor Ligand MEN-14933 Family 13 154
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 1 0
Renin inhibitor 6-[[(2R)-1-[4-[3-[(2-methoxyphenyl)methoxy]pro... 3 1
Disintegrin and metalloproteinase domain-containing protein 17... 3 2
Substance-P receptor ligand (2S,4S)-1-N-(3-chlorophenyl)-2-N-[... 5 2
Stromelysin-1 and Matrix metalloproteinase-9 inhibitor AGN-PC-... 26 12
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 6 11
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Renin and Cytochrome P450 3A4 inhibitor SureCN6719989 family 2 0
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Furin inhibitor phenyl 2-[[(2S)-1-[[(2S)-1-[[(2S)-1-(4-carbami... 2 5
Cathepsin S and Cathepsin K inhibitor SureCN3018173 family 2 4
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 20 23
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
Melanocortin receptor 4 ligand [4-[2-[(1S)-1-amino-3-methylbut... 1 0
Sodium channel protein type 9 subunit alpha ligand SureCN12900... 9 8
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00E... 1 2
Cathepsin K inhibitor N-[2-(4-methoxyanilino)ethyl]-4-methyl-2... 1 1
Disintegrin and metalloproteinase domain-containing protein 17... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00471871 CHEMBL1798004 Bioactive (3S)-7-[2-(hydroxyamino)-2-oxoethoxy]-N-(4-methoxyphenyl)-2-[(2S,3S)-3-methyl-2-[[(2S)-pyrrolidine-2-carbonyl]amino]pentanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide;hydrochloride
CFAMM00471870 CHEMBL1798005 Bioactive (3S)-2-[(2S,3S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-methylpentanoyl]-7-[2-(hydroxyamino)-2-oxoethoxy]-N-(4-methoxyphenyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide;hydrochloride
CFAMM00471860 CHEMBL1797983 Bioactive tert-butyl N-[(2S,3S)-1-[(3S)-7-[2-(hydroxyamino)-2-oxoethoxy]-3-[(4-methoxyphenyl)carbamoyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-1-oxopentan-2-yl]carbamate
CFAMM00471865 CHEMBL1828920 Bioactive (3S)-2-[(2S,3S)-2-(3,3-dimethylbutanoylamino)-3-methylpentanoyl]-7-[2-(hydroxyamino)-2-oxoethoxy]-N-(4-methoxyphenyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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