CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM24821
Family Name Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 inhibitor (6Z)-6-(2-amino-6-ethyl-1H-pyrimidin-4-ylidene)-4-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]cyclohexa-2,4-dien-1-one family
No. of Seeds 9 No. of Other Members 4
Family Centroid CFAMM00471985 Functional Category Bioactive with Natural Product
Superfamily Glucosylceramidase and Cyclin-dependent kinase 1 Binder Superfamily
Class Class 5869

Cousin Family NamesSeedsMembers
Tyrosine kinase Inhibitor PKI166 Family 17 198
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 3 6
Adenosine receptor A1 and Adenosine receptor A2a ligand (6E)-6... 2 2
Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 4 11
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
Cationic trypsin and Prothrombin inhibitor 2-ketobenzothiazole... 1 3
Serine/threonine-protein kinase Chk2 inhibitor (6E)-4-fluoro-6... 3 6


External ID

Functional Category

Molecule Name

CFAMM00471988 CHEMBL1800455 Bioactive (6Z)-6-(2-amino-6-cyclopentyl-1H-pyrimidin-4-ylidene)-4-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]cyclohexa-2,4-dien-1-one
CFAMM00471996 CHEMBL1800449 Bioactive (6Z)-6-(2-amino-1H-pyrimidin-6-ylidene)-4-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]cyclohexa-2,4-dien-1-one
CFAMM00471995 CHEMBL1800464 Bioactive (6Z)-6-[2-amino-4-(cyclopentylamino)-1H-pyrimidin-6-ylidene]-4-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]cyclohexa-2,4-dien-1-one
CFAMM00471986 CHEMBL1800452 Bioactive (6Z)-6-(2-amino-6-propan-2-yl-1H-pyrimidin-4-ylidene)-4-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]cyclohexa-2,4-dien-1-one
CFAMM00471985 CHEMBL1800451 Bioactive (6Z)-6-(2-amino-6-ethyl-1H-pyrimidin-4-ylidene)-4-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]cyclohexa-2,4-dien-1-one
CFAMM00471991 CHEMBL1800465 Bioactive (6Z)-6-[2-amino-4-(cyclohexylamino)-1H-pyrimidin-6-ylidene]-4-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]cyclohexa-2,4-dien-1-one
CFAMM00471984 CHEMBL1800450 Bioactive (6Z)-6-(2-amino-6-methyl-1H-pyrimidin-4-ylidene)-4-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]cyclohexa-2,4-dien-1-one
CFAMM00471990 CHEMBL1800457 Bioactive (6Z)-6-(2-amino-6-cycloheptyl-1H-pyrimidin-4-ylidene)-4-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]cyclohexa-2,4-dien-1-one
CFAMM00471989 CHEMBL1800456 Bioactive (6Z)-6-(2-amino-6-cyclohexyl-1H-pyrimidin-4-ylidene)-4-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]cyclohexa-2,4-dien-1-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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