CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM24851
Family Name Kinesin-like protein KIF11 inhibitor 9-(trifluoromethyl)-1,2,4,11-tetrahydropyrido[3,2-a]carbazol-3-one family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00472074 Functional Category Bioactive
Superfamily Metabotropic glutamate receptor 2 and Kinesin-like protein KIF11 Binder Superfamily
Class Class 3380

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Neuromedin-K receptor Ligand SB222200 Family 17 235
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Fibroblast growth factor receptor 1 and Aurora kinase B Inhibi... 4 51
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
Lethal factor Inhibitor GM6001 Family 50 435
Cyclin-dependent kinase 5 Inhibitor 9-nitropaullone Family 2 13
NF-kappa-B and Protein kinase C zeta type Inhibitor Go6976 Family 9 71
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Serine/threonine-protein kinase Chk1 Inhibitor BIS-IMIDE A Family 1 3
Mineralocorticoid receptor and Androgen receptor Ligand WAY-25... 10 26
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Kinesin-like protein KIF11 Inhibitor 2-(trifluoromethyl)-9h-ca... 5 0
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935258 family 7 2
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Melanin-concentrating hormone receptor 1 ligand SureCN6198980 ... 13 0
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 1 0
C-X-C chemokine receptor type 2 and Cytochrome P450 2C9 ligand... 1 7
Mitogen-activated protein kinase kinase kinase 11 and Mitogen-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00472074 CHEMBL1802989 Bioactive 9-(trifluoromethyl)-1,2,4,11-tetrahydropyrido[3,2-a]carbazol-3-one
CFAMM00472073 CHEMBL1802990 Bioactive 8-(trifluoromethyl)-1,3,4,10-tetrahydropyrido[2,3-b]carbazol-2-one
CFAMM00472077 CHEMBL1803019 Bioactive 7-(trifluoromethyl)-3,9-dihydro-1H-pyrrolo[2,3-b]carbazol-2-one
CFAMM00472076 CHEMBL1803017 Bioactive [7-(trifluoromethyl)-9H-carbazol-2-yl]urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27298 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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