CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM24867
Family Name Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluorophenyl)-2-(2-methylpropyl)quinolin-6-yl]oxyacetamide family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00472147 Functional Category Bioactive
Superfamily cAMP and Dipeptidyl peptidase 4 Binder Superfamily
Class Class 866

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Squalene synthase Inhibitor ER-119884 Family 2 3
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Coagulation factor X and Anionic trypsin-2 inhibitor AGN-PC-07... 1 1
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Cathepsin K inhibitor (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-meth... 3 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[4... 7 4
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 3 5
Disintegrin and metalloproteinase domain-containing protein 17... 8 0
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Prothrombin and Trypsin-1 inhibitor AGN-PC-074I4I family 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Proteinase-activated receptor 1 ligand (3R,3aS,4S,4aR,8aS,9aR)... 1 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 18 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R,... 2 0
Proteinase-activated receptor 1 ligand 2-[2-[(E)-2-[(3R,3aS,4S... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00472148 CHEMBL1808465 Bioactive methyl 2-[3-(aminomethyl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]oxyacetate;hydrochloride
CFAMM00472147 CHEMBL1808463 Bioactive 2-[3-(aminomethyl)-4-(4-fluorophenyl)-2-(2-methylpropyl)quinolin-6-yl]oxyacetamide
CFAMM00472146 CHEMBL1809263 Bioactive 2-[3-(aminomethyl)-4-(3-fluorophenyl)-2-(2-methylpropyl)quinolin-6-yl]oxyacetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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