CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM24872
Family Name Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl)pyridin-3-yl]pyrrolidin-1-yl]-cyclobutylmethanone family
No. of Seeds 1 No. of Other Members 2
Family Centroid CFAMM00472167 Functional Category Bioactive
Superfamily Metabotropic glutamate receptor 5 and Metabotropic glutamate receptor 2 Binder Superfamily
Class Class 3433

Cousin Family NamesSeedsMembers
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
D(2) dopamine receptor Ligand Sertindole Family 3 173
Farnesyltransferase beta subunit, putative Inhibitor Lonafarni... 36 87
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Vasopressin V1b receptor ligand 2-[3-(3-chlorophenyl)-1-oxo-7-... 2 12
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 8 1
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
C-C chemokine receptor type 2 ligand (E)-3-(3,4-dichlorophenyl... 3 2
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 17
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00472167 CHEMBL1808871 Bioactive [2-[6-(3-chlorophenyl)pyridin-3-yl]pyrrolidin-1-yl]-cyclobutylmethanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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