CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2492
Family Name Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family
No. of Seeds 2 No. of Other Members 5
Family Centroid CFAMM00334776 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 2A and Mitogen-activated protein kinase 14 Binder Superfamily
Class Class 840

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Prothrombin Inhibitor Ximelegatran Family 8 157
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Neuromedin-K receptor Ligand SB222200 Family 17 235
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Hepatocyte growth factor receptor Ligand MK-8033 Family 19 42
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Interleukin-1 beta and Interleukin-6 Inhibitor Ibudilast Family 2 11
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
PHA848125 family 13 138
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 4
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Adenosine receptor A1 and Adenosine receptor A2a Ligand FK-838... 4 19
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Adenosine receptor A3 Ligand 2-phenyl-2h-pyrazolo[4,3-d]pyrimi... 2 7
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Glutamate receptor 1 Ligand Piriqualone Family 8 67
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
5-hydroxytryptamine receptor 2A ligand AGN-PC-04RTMN family 7 5
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Metabotropic glutamate receptor 2 and Metabotropic glutamate r... 5 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Metabotropic glutamate receptor 1 ligand GTPL6334 family 6 4
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 3 5
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyr... 3 1
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 6 1
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 18
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 2 2
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 1 3
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4... 5 3
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 1 1
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Coagulation factor X inhibitor AGN-PC-0749DA family 3 2
Coagulation factor X inhibitor AGN-PC-02WFR7 family 7 13
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 3 2
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Melanin-concentrating hormone receptor 1 ligand SureCN4917950 ... 3 5
D(3) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 2 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
Tyrosine-protein kinase receptor TYRO3 ligand 3-amino-6-(1H-in... 2 3
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 4 0
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 7 2
Lutropin-choriogonadotropic hormone receptor ligand 5-[2-(4-te... 1 1
Vascular endothelial growth factor receptor 2 and Vascular end... 5 9
Vascular endothelial growth factor receptor 2 and Vascular end... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00334779 CHEMBL1271550 Bioactive AGN-PC-09M4VY
CFAMM00334776 CHEMBL1271498 Bioactive AGN-PC-09M6D1

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26233 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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