CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2493
Family Name Mitogen-activated protein kinase 14 inhibitor (E)-3-(2,6-dichlorophenyl)-N-[4-[5-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-4-yl]pyridin-2-yl]prop-2-enamide family
No. of Seeds 1 No. of Other Members 1
Family Centroid CFAMM00334785 Functional Category Bioactive
Superfamily Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2-yl)quinoxaline Superfamily
Class Class 2257

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 21
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Fatty-acid amide hydrolase 1 and Acetylcholinesterase inhibito... 12 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Glucocorticoid receptor ligand 3-[1-(3-chloro-4-fluorophenyl)i... 2 0
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Mitogen-activated protein kinase 14 inhibitor SureCN828349 family 1 0
Gonadotropin-releasing hormone receptor ligand AGN-PC-00AWCA f... 1 0
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NS1A family 7 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00334785 CHEMBL1271501 Bioactive (E)-3-(2,6-dichlorophenyl)-N-[4-[5-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-4-yl]pyridin-2-yl]prop-2-enamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46040 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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