CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM24953
Family Name Hepatocyte growth factor receptor ligand [4-[6-amino-5-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]phenyl]-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]methanone family
No. of Seeds 5 No. of Other Members 1
Family Centroid CFAMM00472502 Functional Category Bioactive
Superfamily Hepatocyte growth factor receptor and Macrophage colony-stimulating factor 1 receptor Binder Superfamily
Class Class 2014

Cousin Family NamesSeedsMembers
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Melanocortin receptor 4 ligand N-[(2R)-3-(2,4-dichlorophenyl)-... 2 2
Motilin receptor ligand SureCN2765637 family 1 1
Macrophage colony-stimulating factor 1 receptor ligand [4-[5-a... 1 4


External ID

Functional Category

Molecule Name

CFAMM00472503 CHEMBL1824877 Bioactive [4-[6-amino-5-[1-(2,6-dichlorophenyl)ethoxy]pyridin-3-yl]phenyl]-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]methanone
CFAMM00472502 CHEMBL1824878 Bioactive [4-[6-amino-5-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]phenyl]-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]methanone
CFAMM00472507 CHEMBL1824886 Bioactive [4-[6-amino-5-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]phenyl]-[(3R,5S)-3,5-dimethylpiperazin-1-yl]methanone
CFAMM00472506 CHEMBL1824884 Bioactive [4-[6-amino-5-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone
CFAMM00472505 CHEMBL1824885 Bioactive 4-[6-amino-5-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]-N-(2-pyrrolidin-1-ylethyl)benzamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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Computer-aided Drug Design
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