CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2498
Family Name 5-hydroxytryptamine receptor 3A ligand 2-[(3S)-3-ethylmorpholin-4-yl]-N-[(1R,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-1,3-benzoxazole-4-carboxamide family
No. of Seeds 10 No. of Other Members 18
Family Centroid CFAMM00334865 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 3A and Menin Binder Superfamily
Class Class 828

Cousin Family NamesSeedsMembers
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Benoxapr... 1 76
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
Vascular endothelial growth factor receptor 1 and Vascular end... 4 44
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 1 4
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[3-(1,3-be... 3 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 5 25
Somatostatin receptor type 5 and Potassium voltage-gated chann... 2 21
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 21
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
5-hydroxytryptamine receptor 3A and Potassium voltage-gated ch... 1 0
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Cannabinoid receptor 2 ligand [4-(5-tert-butyl-1,3-benzoxazol-... 4 1
Fatty-acid amide hydrolase 1 inhibitor 2-(1,3-dihydroisoindol-... 2 3
Melanin-concentrating hormone receptor 1 ligand N-[3-(2-aminoq... 4 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 7
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and Dual 3',5'... 27 20
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S,... 2 3
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(1,3-benzoxazol... 3 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[(2S,5S)-5-(... 20 10
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 5 2
Cathepsin S and Cathepsin L1 inhibitor (2S)-2-(1,3-benzoxazol-... 1 9
Cathepsin S and Cathepsin L1 inhibitor SureCN5361439 family 2 4
5-hydroxytryptamine receptor 6 ligand SureCN3910449 family 3 15
Somatostatin receptor type 5 ligand SureCN3572493 family 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00334849 CHEMBL1271731 Bioactive 2-[(3S,5S)-3,5-dimethylmorpholin-4-yl]-N-[(1R,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-1,3-benzoxazole-4-carboxamide
CFAMM00334842 CHEMBL1271790 Bioactive N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-2-[(3S,5S)-3,5-dimethylmorpholin-4-yl]-1,3-benzoxazole-4-carboxamide
CFAMM00334841 CHEMBL1271791 Bioactive 2-[(3S,5S)-3-ethyl-5-methylmorpholin-4-yl]-N-[(1R,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-1,3-benzoxazole-4-carboxamide
CFAMM00334853 CHEMBL1271678 Bioactive N-[(1R,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-2-[(3S)-3-(2-methylpropyl)morpholin-4-yl]-1,3-benzoxazole-4-carboxamide
CFAMM00334852 CHEMBL1271629 Bioactive N-[(1R,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-2-[(3S)-3-propylmorpholin-4-yl]-1,3-benzoxazole-4-carboxamide
CFAMM00334865 CHEMBL1271628 Bioactive 2-[(3S)-3-ethylmorpholin-4-yl]-N-[(1R,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-1,3-benzoxazole-4-carboxamide
CFAMM00334851 CHEMBL1271677 Bioactive N-[(1R,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-2-[(3S)-3-propan-2-ylmorpholin-4-yl]-1,3-benzoxazole-4-carboxamide
CFAMM00334850 CHEMBL1271730 Bioactive 2-[(3S)-3-tert-butylmorpholin-4-yl]-N-[(1R,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-1,3-benzoxazole-4-carboxamide
CFAMM00334843 CHEMBL1271960 Bioactive 2-[(2S,6S)-2,6-dimethylpiperazin-1-yl]-N-[(1R,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-1,3-benzoxazole-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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