CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2499
Family Name P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-3-methyl-1-(2-methylpyridin-3-yl)-2-oxoimidazolidine-4-carboxamide family
No. of Seeds 9 No. of Other Members 31
Family Centroid CFAMM00334882 Functional Category Bioactive with Natural Product
Superfamily P2X purinoceptor 7 and Beta-lactamase Binder Superfamily 2
Class Class 2253

Cousin Family NamesSeedsMembers
Transient receptor potential cation channel subfamily V member... 16 295
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 19 186
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 6-(4-... 3 6
Prothrombin inhibitor SureCN7371121 family 13 3
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor AG... 5 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 5 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 1 0
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 6 3
P2X purinoceptor 7 inhibitor SureCN1635928 family 4 4
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 1 2
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00334898 CHEMBL2218165 Bioactive (4S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-1-(6-fluoropyridin-3-yl)-3-methyl-2-oxoimidazolidine-4-carboxamide
CFAMM00334882 CHEMBL1271656 Bioactive (4S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-3-methyl-1-(2-methylpyridin-3-yl)-2-oxoimidazolidine-4-carboxamide
CFAMM00334902 CHEMBL1271826 Bioactive (4S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-3-methyl-1-(2-methylpyridin-4-yl)-2-oxoimidazolidine-4-carboxamide
CFAMM00334867 CHEMBL2218519 Bioactive (4S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-3-methyl-1-(6-methylpyridin-3-yl)-2-oxoimidazolidine-4-carboxamide
CFAMM00334880 CHEMBL1271939 Bioactive (4S)-N-[(2,4-dichlorophenyl)methyl]-3-methyl-1-(2-methylpyridin-3-yl)-2-oxoimidazolidine-4-carboxamide
CFAMM00334873 CHEMBL2218365 Bioactive (4S)-N-[(2-chloro-3,4-difluorophenyl)methyl]-1-(2-chloropyridin-3-yl)-3-methyl-2-oxoimidazolidine-4-carboxamide
CFAMM00334879 CHEMBL2218366 Bioactive (4S)-1-(2-chloropyridin-3-yl)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-3-methyl-2-oxoimidazolidine-4-carboxamide
CFAMM00334900 CHEMBL2218098 Bioactive (4S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-1-(2,6-dimethylpyridin-3-yl)-3-methyl-2-oxoimidazolidine-4-carboxamide
CFAMM00334892 CHEMBL2218357 Bioactive (4S)-1-(2-chloropyridin-3-yl)-N-[(2,4-dichlorophenyl)methyl]-3-methyl-2-oxoimidazolidine-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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