CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8362034 family
No. of Seeds 17 No. of Other Members 3
Family Centroid CFAMM00309460 Functional Category Bioactive
Superfamily cGMP-specific 3',5'-cyclic phosphodiesterase and Adenosine receptor A2b Binder Superfamily
Class Class 253

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Avanafi... 3 16
Adenosine receptor A2a Ligand KW-6002 Family 18 195
GP-531 family 1 33
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN1... 6 16
Adenosine receptor A1 and Adenosine receptor A2b ligand 3-meth... 7 19
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-[4-[... 12 15
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
Prelamin-A/C inhibitor CHEMBL1501476 family 1 2
Survival motor neuron protein and Microtubule-associated prote... 2 14
C-X-C chemokine receptor type 3 ligand 3-amino-6-chloro-5-[(3S... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 13 2
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 10 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
P2X purinoceptor 7 inhibitor (7R)-1-[(3,4-difluorophenyl)methy... 1 0


External ID

Functional Category

Molecule Name

CFAMM00309464 CHEMBL25419 Bioactive (7R)-7-benzyl-3-[(3-chloro-4-methoxyphenyl)methyl]-5-ethyl-4-oxo-7,8-dihydroimidazo[2,1-b]purine-2-carboxamide
CFAMM00309478 CHEMBL25311 Bioactive SureCN8361546
CFAMM00309471 CHEMBL24587 Bioactive (7R)-7-benzyl-3-[(3-chloro-4-hydroxyphenyl)methyl]-5-ethyl-4-oxo-7,8-dihydroimidazo[2,1-b]purine-2-carboxamide
CFAMM00309463 CHEMBL106180 Bioactive 7-[(3-chloro-4-methoxyphenyl)methyl]-8-(cyclohexylamino)-1,3-diethylpurine-2,6-dione
CFAMM00309477 CHEMBL24543 Bioactive CHEMBL24543
CFAMM00309470 CHEMBL26102 Bioactive CHEMBL26102
CFAMM00309461 CHEMBL323473 Bioactive 7-[(3-chloro-4-hydroxyphenyl)methyl]-8-(cyclohexylamino)-1,3-diethylpurine-2,6-dione
CFAMM00309476 CHEMBL23572 Bioactive SureCN8358716
CFAMM00309468 CHEMBL110595 Bioactive 7-[(3-chloro-4-methoxyphenyl)methyl]-8-(cyclopentylamino)-1,3-diethylpurine-2,6-dione
CFAMM00309460 CHEMBL24815 Bioactive SureCN8362034
CFAMM00309475 CHEMBL26229 Bioactive SureCN8360075
CFAMM00309467 CHEMBL23123 Bioactive SureCN8358726
CFAMM00309459 CHEMBL280699 Bioactive CHEMBL280699
CFAMM00309458 CHEMBL25985 Bioactive CHEMBL25985
CFAMM00309473 CHEMBL23375 Bioactive CHEMBL23375
CFAMM00309479 CHEMBL106447 Bioactive 7-[(3-chloro-4-hydroxyphenyl)methyl]-8-(cyclopentylamino)-1,3-diethylpurine-2,6-dione
CFAMM00309472 CHEMBL285610 Bioactive CHEMBL285610

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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