CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM25005
Family Name Caspase-3 and Caspase-7 inhibitor valine aspartyl ketone 16 family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00472703 Functional Category Bioactive
Superfamily Neprilysin and Caspase-3 Binder Superfamily
Class Class 3300

Cousin Family NamesSeedsMembers
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Penicillin binding protein inhibitor β-lactam cephalosporin Ce... 3 38
Penicillin binding protein Inhibitor Cefadroxil Family 5 17
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Neuromedin-K receptor Ligand Senktide Family 15 22
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Gamma-g... 2 1
Cruzipain Inhibitor WRR-204 Family 18 35
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Pol polyprotein inhibitor benzyl N-[(2S,3R)-4-[(3aR,6S,7aS)-6-... 3 2
Caspase-3 and Caspase-7 inhibitor valine aspartyl ketone 31 fa... 1 8
Caspase-3 and Caspase-7 inhibitor (3S)-5-benzylsulfanyl-3-[[(2... 1 2
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3R)-1-cyclohexyl-3-h... 2 0


External ID

Functional Category

Molecule Name

CFAMM00472704 CHEMBL183564 Bioactive valine aspartyl ketone 21
CFAMM00472703 CHEMBL183760 Bioactive valine aspartyl ketone 16
CFAMM00472702 CHEMBL2096776 Bioactive valine aspartyl ketone 17

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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Computer-aided Drug Design
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