CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2518
Family Name Pol polyprotein and Cytochrome P450 3A4 inhibitor P3 arylpyrrole analog 3 family
No. of Seeds 19 No. of Other Members 1
Family Centroid CFAMM00321109 Functional Category Bioactive
Superfamily Pol polyprotein and Cytochrome P450 3A4 Binder Superfamily
Class Class 3351

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Pol polyprotein inhibitor AC1LARNY family 28 17
Pol polyprotein inhibitor (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5... 12 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Pol polyprotein inhibitor pyridylthiophene analog 10 family 3 0
Pol polyprotein inhibitor ethyl)-amide family 4 0
Pol polyprotein inhibitor pyridylthiophene analog 16 family 4 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Pol polyprotein inhibitor pyridylfuran analog 14 family 6 0
Beta-3 adrenergic receptor ligand 6-[4-[2-[[(2S)-3-[(3,3-dimet... 6 7
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 1 4
Pol polyprotein and Cytochrome P450 3A4 inhibitor (2S)-4-(3a,6... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15


External ID

Functional Category

Molecule Name

CFAMM00335037 CHEMBL128395 Bioactive P3 arylpyrrole analog 20
CFAMM00335025 CHEMBL131994 Bioactive P3 arylpyrrole analog 6
CFAMM00335031 CHEMBL334572 Bioactive P3 arylpyrrole analog 15
CFAMM00335036 CHEMBL341176 Bioactive P3 arylpyrrole analog 12
CFAMM00335035 CHEMBL340733 Bioactive P3 arylpyrrole analog 17
CFAMM00335029 CHEMBL337701 Bioactive P3 arylpyrrole analog 8
CFAMM00335034 CHEMBL437449 Bioactive P3 arylpyrrole analog 4
CFAMM00335040 CHEMBL340729 Bioactive P3 arylpyrrole analog 11
CFAMM00335028 CHEMBL276121 Bioactive P3 arylpyrrole analog 10
CFAMM00335039 CHEMBL131941 Bioactive P3 arylpyrrole analog 9
CFAMM00335027 CHEMBL337449 Bioactive P3 arylpyrrole analog 7
CFAMM00335033 CHEMBL338142 Bioactive P3 arylpyrrole analog 19
CFAMM00335038 CHEMBL334573 Bioactive P3 arylpyrrole analog 14
CFAMM00335026 CHEMBL406460 Bioactive P3 arylpyrrole analog 5
CFAMM00335032 CHEMBL128336 Bioactive P3 arylpyrrole analog 16

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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