CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2520
Family Name Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 family
No. of Seeds 8 No. of Other Members 1
Family Centroid CFAMM00335072 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase B-raf and Phosphatidylinositol 3-kinase regulatory subunit alpha Binder Superfamily
Class Class 1024

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Type-1 angiotensin II receptor Ligand Forasartan Family 3 253
Type-1 angiotensin II receptor Ligand Tasosartan Family 10 29
Mast/stem cell growth factor receptor Kit and Vascular endothe... 6 34
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 15 457
Hepatocyte growth factor receptor Ligand SGX523 Family 1 15
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
HER Inhibitor AC480 Family 4 67
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 53
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Aurora kinase A Inhibitor ABT-348 Family 20 49
SCH-900776 family 8 14
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Transient receptor potential cation channel subfamily V member... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
C-X-C chemokine receptor type 4 and Envelope glycoprotein gp16... 2 2
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-09M46L fa... 2 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase B-raf inhibitor SureCN3495829 ... 24 0
Serine/threonine-protein kinase B-raf inhibitor SureCN1013857 ... 9 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Cellular tumor antigen p53 inhibitor CHEMBL1318500 family 1 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14574... 1 2
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Serine/threonine-protein kinase Chk1 and Cyclin-A2 inhibitor S... 1 1
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Insulin-like growth factor 1 receptor and Insulin receptor lig... 1 1
Mitogen-activated protein kinase 10 and Transcription factor A... 4 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 9 3
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 1 4
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Casein kinase II subunit alpha inhibitor AGN-PC-0766PM family 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 0
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 2
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 0
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Protein kinase C zeta type and Cyclin-dependent kinase 2 inhib... 2 13
3-phosphoinositide-dependent protein kinase 1 and MAP kinase-a... 1 5
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 12 7
Transient receptor potential cation channel subfamily V member... 4 0
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 15
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Casein kinase II subunit alpha inhibitor 7-(cyclopropylamino)-... 1 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 5
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Fibroblast growth factor receptor 1 and Vascular endothelial g... 5 0
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Metabotropic glutamate receptor 2 ligand 3-(cyclopropylmethyl)... 1 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Somatostatin receptor type 3 and Somatostatin receptor type 4 ... 5 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Tyrosine-protein kinase ABL1 and Abelson tyrosine-protein kina... 3 0
Serine/threonine-protein kinase ATR and Serine/threonine-prote... 8 10
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 1 0
Protein kinase C theta type and Protein kinase C delta type in... 2 1
Protein kinase C theta type and Protein kinase C delta type in... 9 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Type-1 angiotensin II receptor ligand 5-[2-[4-[[4-butyl-3-[[4-... 4 2
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Motilin receptor ligand SureCN2004322 family 2 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 2 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 9 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
ALK tyrosine kinase receptor ligand 3-[1-[(3-fluorophenyl)meth... 2 0
D(3) dopamine receptor and Muscarinic acetylcholine receptor M... 8 2
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 4 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cyclin-dependent kinase 1 inhibitor N-[[5-[(3Z)-3-[4-(methoxym... 3 7
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 5
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1-met... 2 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 4
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Type-1 angiotensin II receptor ligand SureCN7390271 family 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Epidermal growth factor receptor ligand AGN-PC-073LJS family 4 0
Type-1B angiotensin II receptor ligand SureCN9309010 family 5 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 3 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
High affinity nerve growth factor receptor ligand SureCN490352... 3 0
Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... 4 0
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Mitogen-activated protein kinase 8 inhibitor N-[4-[4-[2-(cyclo... 1 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 11 1
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0
Serine/threonine-protein kinase B-raf inhibitor (2R)-1-[3-[3-(... 1 0
Serine/threonine-protein kinase B-raf inhibitor SureCN3496211 ... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00335072 CHEMBL584942 Bioactive SureCN3495787
CFAMM00335065 CHEMBL570458 Bioactive SureCN3495699
CFAMM00335064 CHEMBL570453 Bioactive SureCN3497315
CFAMM00335070 CHEMBL1276188 Bioactive SureCN3495782
CFAMM00335069 CHEMBL1276187 Bioactive SureCN1019960
CFAMM00335068 CHEMBL1276182 Bioactive 7-[4-fluoro-2-[(1R,4R)-2-methyl-2-azabicyclo[2.2.1]heptan-5-yl]phenyl]-3-(1H-indazol-4-yl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
CFAMM00335067 CHEMBL570658 Bioactive SureCN3496013
CFAMM00335066 CHEMBL584527 Bioactive SureCN3496542

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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