CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2521
Family Name Serine/threonine-protein kinase B-raf inhibitor SureCN1013857 family
No. of Seeds 9 No. of Other Members 3
Family Centroid CFAMM00335077 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase B-raf and Phosphatidylinositol 3-kinase regulatory subunit alpha Binder Superfamily
Class Class 1024

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
HER Inhibitor AC480 Family 4 67
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 53
GDC-0349 family 44 77
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Aurora kinase A inhibitor AGN-PC-07ZZEH family 2 4
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
cGMP-specific 3',5'-cyclic phosphodiesterase and Potassium vol... 13 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 13
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 3
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase B-raf inhibitor SureCN3495829 ... 24 0
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Survival motor neuron protein and Menin inhibitor CHEMBL132797... 1 1
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Mitogen-activated protein kinase 10 and Transcription factor A... 4 4
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Transient receptor potential cation channel subfamily V member... 4 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Scavenger receptor class B member 1 ligand 9-[3-(4,6-diethylpy... 2 0
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Serine/threonine-protein kinase ATR and Serine/threonine-prote... 8 10
Protein kinase C theta type and Protein kinase C delta type in... 9 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Proto-oncogene tyrosine-protein kinase Src and Mast/stem cell ... 4 1
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Epidermal growth factor receptor ligand Pyrroloquinazoline der... 7 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Epidermal growth factor receptor ligand AGN-PC-073LJS family 4 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... 4 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0
Serine/threonine-protein kinase B-raf inhibitor (2R)-1-[3-[3-(... 1 0
Serine/threonine-protein kinase B-raf inhibitor SureCN3496211 ... 2 0
Insulin-like growth factor 1 receptor ligand SureCN2967184 family 2 3
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00335078 CHEMBL570681 Bioactive SureCN1017689
CFAMM00335084 CHEMBL1276189 Bioactive SureCN3497448
CFAMM00335077 CHEMBL585334 Bioactive SureCN1013857
CFAMM00335083 CHEMBL1277056 Bioactive SureCN1019780
CFAMM00335076 CHEMBL585335 Bioactive ethyl 3-[3-(1H-indazol-4-yl)-6-methyl-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]-8-azabicyclo[3.2.1]octane-8-carboxylate
CFAMM00335082 CHEMBL583133 Bioactive SureCN1016410
CFAMM00335075 CHEMBL1276190 Bioactive SureCN3497413
CFAMM00335074 CHEMBL1276192 Bioactive SureCN1017167
CFAMM00335073 CHEMBL571744 Bioactive SureCN1013585

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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