CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2525
Family Name Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)ethylcarbamoyl]-4-amino-5-hydroxy-8-methyl-2-propan-2-ylnonyl]-2-(4-methoxybutoxy)benzamide family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00335092 Functional Category Bioactive
Superfamily Glucan synthesis regulatory protein Inhibitor Anidulafungin Superfamily
Class Class 322

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Renin Inhibitor Aliskiren Family 28 107
Zucapsacin family 7 177
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Substance-P receptor Ligand DA-5018 Family 14 73
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 23
Ceramide glucosyltransferase Inhibitor Eliglustat Tartrate Family 3 2
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5R)-5-benzyl-3-... 2 3
Pol polyprotein inhibitor 180968-31-4 family 8 13
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Pol polyprotein inhibitor (2R,3R,4R,5R)-2,3,4-trihydroxy-N,N'-... 3 3
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Prothrombin inhibitor N-cyclohexyl-3-[3-(diaminomethylideneami... 3 4
Pol polyprotein inhibitor MK-944a family 6 1
Serine palmitoyltransferase 1 and Serine palmitoyltransferase ... 2 1
Carbonic anhydrase 9 and Carbonic anhydrase 14 inhibitor N-[2-... 6 10
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Renin inhibitor [(1S,3R,4S)-3-amino-4-hydroxycyclopentyl]-[(3R... 2 3
Pol polyprotein inhibitor (2R)-2-benzyl-5-[(3S,5R)-3-benzyl-5-... 11 5
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Pol polyprotein inhibitor L-689,502 family 17 2
5-hydroxytryptamine receptor 1A ligand (3S)-3-[4-(7,9-dioxo-8-... 2 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (5Z,8... 4 2
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5... 3 8
Pol polyprotein inhibitor AC1LA3AI family 5 9
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
Beta-secretase 1 inhibitor N-[(2S,3R)-1-(3,5-difluorophenyl)-3... 5 5
Pol polyprotein inhibitor AC1LA3B0 family 1 2
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
Renin inhibitor methyl N-[[5-[[(2S,3S,5R)-2-amino-6-(butylamin... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
5-hydroxytryptamine receptor 1A ligand AGN-PC-074R8E family 2 1
Renin inhibitor (4S,5S,7S)-5-amino-N-butyl-7-[[4-tert-butyl-3-... 2 2
Pol polyprotein inhibitor N-[(2S,3R,4R,5R)-1-cyclohexyl-3,4-di... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00335092 CHEMBL1276272 Bioactive N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)ethylcarbamoyl]-4-amino-5-hydroxy-8-methyl-2-propan-2-ylnonyl]-2-(4-methoxybutoxy)benzamide
CFAMM00335091 CHEMBL1783186 Bioactive SureCN6042314

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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