CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM25264
Family Name Serine/threonine-protein kinase mTOR inhibitor 3-(cyclohexylmethyl)-5-[4-(hydroxymethyl)phenyl]-1H-imidazo[4,5-b]pyrazin-2-one family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00473669 Functional Category Bioactive
Superfamily Thromboxane A2 receptor Ligand Bibv 308 Superfamily
Class Class 960

Cousin Family NamesSeedsMembers
Eluxadoline family 4 85
Tyrosine kinase Inhibitor PKI166 Family 17 198
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 7 3
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 3... 2 10
Neuropeptide Y receptor type 5 ligand AGN-PC-07R6YQ family 7 7
Neuropeptide Y receptor type 5 ligand SureCN4170426 family 4 13
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 3-methyl-4... 15 14
Lysine--tRNA ligase inhibitor 4-[[2-(2-piperazin-1-ylpyridin-4... 2 0
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 f... 2 18
Glucocorticoid receptor ligand SureCN12238714 family 16 4
Calcitonin gene-related peptide type 1 receptor ligand N-[5-(4... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00473669 CHEMBL1945796 Bioactive 3-(cyclohexylmethyl)-5-[4-(hydroxymethyl)phenyl]-1H-imidazo[4,5-b]pyrazin-2-one
CFAMM00473671 CHEMBL1945950 Bioactive 3-(cyclohexylmethyl)-5-[4-(2-hydroxypropan-2-yl)phenyl]-1H-imidazo[4,5-b]pyrazin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26853 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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