CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2527
Family Name Renin inhibitor 6-[[(2R)-1-[4-[3-[(2-methoxyphenyl)methoxy]propoxy]phenyl]-6-oxopiperazin-2-yl]methylsulfanyl]-4-(3-methoxypropyl)-4a,8a-dihydro-1,4-benzoxazin-3-one family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00335101 Functional Category Bioactive
Superfamily Renin and Beta-lactamase Binder Superfamily
Class Class 1550

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Substance-K receptor Ligand MEN-14933 Family 13 154
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Renin Inhibitor Ro-66-1168 Family 10 30
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 8 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Substance-P receptor ligand (2S,4S)-1-N-(3-chlorophenyl)-2-N-[... 5 2
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Renin and Cytochrome P450 3A4 inhibitor SureCN6719989 family 2 0
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Cathepsin S and Cathepsin K inhibitor SureCN3018173 family 2 4
C-C chemokine receptor type 1 ligand N-[2-[(2S)-3-(5-chlorospi... 5 0
C-C chemokine receptor type 1 ligand N-[2-[(2S)-2-amino-3-(5-f... 3 0
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
P2X purinoceptor 7 inhibitor SureCN3722920 family 4 0
Hepatocyte growth factor receptor ligand 5-[(1R)-1-(2,6-dichlo... 1 0
Neuropeptide Y receptor type 5 ligand SureCN3380276 family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00335103 CHEMBL1276279 Bioactive 6-[[(2R)-1-[4-[3-[(2-methoxyphenyl)methoxy]propoxy]phenyl]-6-oxopiperazin-2-yl]methoxy]-4-(3-methoxypropyl)-4a,8a-dihydro-1,4-benzoxazin-3-one
CFAMM00335102 CHEMBL205345 Bioactive SureCN6717233
CFAMM00335101 CHEMBL1276280 Bioactive 6-[[(2R)-1-[4-[3-[(2-methoxyphenyl)methoxy]propoxy]phenyl]-6-oxopiperazin-2-yl]methylsulfanyl]-4-(3-methoxypropyl)-4a,8a-dihydro-1,4-benzoxazin-3-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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