CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM25286
Family Name Lysosomal Pro-X carboxypeptidase inhibitor 4-[6-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]pyrimidin-4-yl]-2-(4-methoxyphenyl)morpholine family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00473721 Functional Category Bioactive
Superfamily Coagulation factor X and Lysosomal Pro-X carboxypeptidase Binder Superfamily
Class Class 5910

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Tyrosine kinase Inhibitor PKI166 Family 17 198
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 9 3
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 4 4
Histamine H4 receptor ligand AGN-PC-00FEQJ family 2 3
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 4 2
Arachidonate 15-lipoxygenase inhibitor SureCN14288120 family 3 12
Collagenase 3 inhibitor 5-[4-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Melanin-concentrating hormone receptor 1 ligand SureCN5431614 ... 1 2
Sterol O-acyltransferase 1 inhibitor 1,1-bis[5-[[4,5-bis(4-met... 1 15
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Glucagon receptor ligand SureCN2647807 family 3 7
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 2 0
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 2 1
Lysosomal Pro-X carboxypeptidase inhibitor 1-[6-[(2S)-2-(5,6-d... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00473724 CHEMBL237828 Bioactive AGN-PC-04S2VT
CFAMM00473721 CHEMBL1950904 Bioactive 4-[6-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]pyrimidin-4-yl]-2-(4-methoxyphenyl)morpholine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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