CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM2539
Family Name 5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family
No. of Seeds 10 No. of Other Members 8
Family Centroid CFAMM00335208 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 3A Binder Superfamily
Class Class 824

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Delavirdine Family 1 68
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Class II cytokine receptor Ligand IL-10 Family 7 45
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Poly [ADP-ribose] polymerase 1 Inhibitor 2-ethylquinoline-8-ca... 3 4
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Metabotropic glutamate receptor 5 Ligand 3-chloro-n-(6-chlorop... 2 5
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(6-methylpy... 4 3
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Adenosine receptor A3 Ligand 2-aminoquinazoline-4-carboxyanili... 4 3
Arachidonate 5-lipoxygenase Inhibitor Methyl 2-(benzylamino)-1... 3 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Urotensin-2 receptor Ligand Palosuran Family 4 4
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 6-(4-... 3 6
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 3
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07ZA4D family 1 0
Integrin beta-3 and Integrin alpha-V inhibitor SureCN547914 fa... 8 32
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 9
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 12
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZBAK family 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
Gonadotropin-releasing hormone receptor ligand AGN-PC-075KV1 f... 4 1
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Glucosylceramidase and Alpha-galactosidase A inhibitor AC1NNEG... 4 5
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(3,4-di... 3 1
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
Beta-secretase 1 inhibitor 3-[2-amino-6-(2-methylphenyl)quinol... 5 2
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 9 6
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-2-ylpi... 1 0
Substance-P receptor ligand Netupitant family 5 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Microsomal triglyceride transfer protein large subunit inhibit... 13 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor 6-... 1 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 2 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 7 7
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(3-fluor... 10 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Adenosine receptor A1 and Adenosine receptor A3 ligand CHEMBL4... 2 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(3-hydroxypr... 2 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquina... 2 0
Acetyl-CoA carboxylase 2 and Acetyl-Coenzyme A carboxylase 2 i... 1 0
Cannabinoid receptor 2 ligand AGN-PC-00SRU5 family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00335206 CHEMBL1278088 Bioactive AGN-PC-008YGE
CFAMM00335205 CHEMBL1278175 Bioactive AGN-PC-009VGL
CFAMM00335198 CHEMBL1276835 Bioactive AGN-PC-006VYQ
CFAMM00335204 CHEMBL1278176 Bioactive AGN-PC-03ZB9A
CFAMM00335203 CHEMBL1276921 Bioactive SureCN3686290
CFAMM00335208 CHEMBL1277560 Bioactive AGN-PC-03ZB72

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46023 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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